Proliferation activity is significantly elevated in partially embolized cerebral arteriovenous malformations
Autor: | Johannes van de Nes, Dietmar Stolke, Claudia A. Dumitru, Yuan Zhu, Ulrich Sure, I. Erol Sandalcioglu, Doreen Wende, Elke R. Gizewski, Siamak Asgari |
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Jazyk: | angličtina |
Rok vydání: | 2010 |
Předmět: |
Adult
Intracranial Arteriovenous Malformations Male Vascular Endothelial Growth Factor A Pathology medicine.medical_specialty Adolescent Angiogenesis medicine.medical_treatment Medizin Antigens CD34 Pathogenesis Young Adult Text mining medicine Humans Embolization Child Aged Cell Proliferation Retrospective Studies biology business.industry Case-control study Arteriovenous malformation Middle Aged medicine.disease Platelet Endothelial Cell Adhesion Molecule-1 Ki-67 Antigen Intracranial Embolism Neurology Case-Control Studies Ki-67 biology.protein Immunohistochemistry Female Fibroblast Growth Factor 2 Neurology (clinical) Cardiology and Cardiovascular Medicine business |
Popis: | Background: The natural history of cerebral arteriovenous malformations (AVMs) is yet to be determined. It has been shown that angiogenic factors are involved in the pathogenesis of AVMs, in particular in partially embolized lesions. This study was conducted to investigate the expression of angiogenic and proliferative factors in relation to different clinical conditions and treatment modalities. Methods: Immunohistochemistry was performed for 145 consecutive cases of cerebral AVMs. The specimens were stained with antibodies against VEGF, bFGF, Ki 67, CD 34 and CD 31. Expression was correlated with clinical presentation (haemorrhage, seizures or other symptoms), AVM localization, size, eloquence and venous drainage, as well as with preoperative AVM embolization. Results: Whereas no correlation was found between the expression of angiogenic factors and different clinical conditions, we observed a significantly increased proliferation activity as shown by Ki 67 expression in patients with intracerebral haemorrhage (p = 0.02) and in patients with preoperative embolization (p = 0.02). Conclusions: Increased proliferation activity in partially embolized AVMs supports a ‘no-touch’ strategy and clinical observation in high-risk AVMs and demands complete AVM elimination in treatable lesions. |
Databáze: | OpenAIRE |
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