Verification of new method for automatic thickness measurement of melanocytic skin tumours by high frequency ultrasound
| Autor: | Loreta Pilipaityte, Jonas Guzaitis, Gintare Linkeviciute, Kristina Sakalauskiene, Skaidra Valiukeviciene, Jurgita Makstiene, Renaldas Raišutis |
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| Rok vydání: | 2018 |
| Předmět: |
Prognostic factor
Materials science Correlation coefficient automatic algorithm lcsh:Mechanical engineering and machinery 030218 nuclear medicine & medical imaging histology 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine 616.5-006.6 [udc] Skin tumours Interquartile range Asymmetric distribution lcsh:TJ1-1570 General Materials Science ultrasound business.industry Mechanical Engineering Ultrasound melanoma thickness melanocytic skin tumors Small range Nuclear medicine business High frequency ultrasound |
| Zdroj: | Journal of Vibroengineering, Vol 20, Iss 1, Pp 651-661 (2018) Journal of vibroengineering, Kaunas : JVE International, 2018, vol. 20, iss. 1, art. no. 2806, p. 651-661 |
| ISSN: | 2538-8460 1392-8716 |
| DOI: | 10.21595/jve.2017.19475 |
| Popis: | Histological thickness of cutaneous melanoma (CM), known as the Breslow index (pT), represents the most important prognostic factor. The objective of this study is to evaluate the reliability of automatic algorithm based on B-scan image processing of 22 MHz ultrasound (US) for measuring the thickness of CM and melanocytic nevi (MN). The thickness of CM (n = 54) and MN (n = 91) has been measured manually (mT) and automatically (aT) using an algorithm based on B-scan image processing of 22 MHz US. All melanocytic skin tumours (MST) were surgically excised and their histological thicknesses (pT) according to Breslow were evaluated. The investigated parameters were expressed as medians with interquartile range (IQR) because of their asymmetric distribution, Spearman’s correlation coefficient was determined as well. An agreement between values of mT/aT and mT/pT was evaluated by using the Bland-Altman plots. We found a good agreement of aT and mT with the moderate bias of 0.08 mm and relatively small range (95 % CI –0.01 to 0.18) in CM, accordingly 0.03 mm (95 % CI 0.00 to 0.07 mm) regarding MN. The medians of mT/pT in cases of CM and MN were 0.96 mm (IQR: 0.65-1.52) / 0.97 (IQR: 0.66-1.62) and 0.51 mm (IQR: 0.37-0.67) / 0.69 mm (IQR: 0.46-1.01) respectively. The parameters of the thickness correlated better in CM (r = 0.86) than in MN (r = 0.64) cases. The difference between manual (mT) and automatic (aT) measurements while evaluating the thickness of MST was non-significant. Therefore, automatic algorithm based on B-scan image processing of 22 MHz US is a reliable tool for measuring the thickness of MST by less experienced operators. |
| Databáze: | OpenAIRE |
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