Phagocytosis genes nonautonomously promote developmental cell death in the Drosophila ovary
| Autor: | Jeffrey D. Taylor, Kimberly McCall, Albert A. Mondragon, Tracy L. Meehan, Claire E. Schenkel, Katherine E. Moynihan, Jon Iker Etchegaray, Alla Yalonetskaya, Allison K. Timmons |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Programmed cell death Multidisciplinary Cell Death Kinase Phagocytosis Ovary Biology Germline Nurse cell Cell biology 03 medical and health sciences 030104 developmental biology PNAS Plus Cytoplasm Apoptosis otorhinolaryngologic diseases DNA fragmentation Animals Drosophila Female |
| Zdroj: | Proceedings of the National Academy of Sciences of the United States of America. 113(9) |
| ISSN: | 1091-6490 |
| Popis: | Programmed cell death (PCD) is usually considered a cell-autonomous suicide program, synonymous with apoptosis. Recent research has revealed that PCD is complex, with at least a dozen cell death modalities. Here, we demonstrate that the large-scale nonapoptotic developmental PCD in the Drosophila ovary occurs by an alternative cell death program where the surrounding follicle cells nonautonomously promote death of the germ line. The phagocytic machinery of the follicle cells, including Draper, cell death abnormality (Ced)-12, and c-Jun N-terminal kinase (JNK), is essential for the death and removal of germ-line-derived nurse cells during late oogenesis. Cell death events including acidification, nuclear envelope permeabilization, and DNA fragmentation of the nurse cells are impaired when phagocytosis is inhibited. Moreover, elimination of a small subset of follicle cells prevents nurse cell death and cytoplasmic dumping. Developmental PCD in the Drosophila ovary is an intriguing example of nonapoptotic, nonautonomous PCD, providing insight on the diversity of cell death mechanisms. |
| Databáze: | OpenAIRE |
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