Design of peptide mimetics to block pro-inflammatory functions of HA fragments
| Autor: | Eva A. Turley, Alexandra Hauser-Kawaguchi, Leonard G. Luyt |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Inflammation Context (language use) Peptide Polysaccharide Extracellular matrix 03 medical and health sciences Biomimetic Materials medicine Animals Humans Hyaluronic Acid Receptor Molecular Biology chemistry.chemical_classification biology CD44 Cell biology Molecular Weight Disease Models Animal 030104 developmental biology chemistry biology.protein medicine.symptom Peptides Homeostasis Signal Transduction |
| Zdroj: | Matrix biology : journal of the International Society for Matrix Biology. |
| ISSN: | 1569-1802 |
| Popis: | Hyaluronan is a simple extracellular matrix polysaccharide that actively regulates inflammation in tissue repair and disease processes. The native HA polymer, which is large (>500 kDa), contributes to the maintenance of homeostasis. In remodeling and diseased tissues, polymer size is strikingly polydisperse, ranging from 500 kDa. In a diseased or stressed tissue context, both smaller HA fragments and high molecular weight HA polymers can acquire pro-inflammatory functions, which result in the activation of multiple receptors, triggering pro-inflammatory signaling to diverse stimuli. Peptide mimics that bind and scavenge HA fragments have been developed, which show efficacy in animal models of inflammation. These studies indicate both that HA fragments are key to driving inflammation and that scavenging these is a viable therapeutic approach to blunting inflammation in disease processes. This mini-review summarizes the peptide-based methods that have been reported to date for blocking HA signaling events as an anti-inflammatory therapeutic approach. |
| Databáze: | OpenAIRE |
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