Diffusion and perfusion MRI quantification in ileal Crohn's disease
| Autor: | Sahar Semaan, Bachir Taouli, Stefanie J. Hectors, Octavia Bane, Xiaoyu Jia, Robert Hirten, Jean-Frederic Colombel, Sonja Gordic |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Contrast Media Perfusion scanning 030218 nuclear medicine & medical imaging Diffusion 03 medical and health sciences Motion Young Adult 0302 clinical medicine Crohn Disease Ileum medicine Humans Radiology Nuclear Medicine and imaging Prospective Studies skin and connective tissue diseases Prospective cohort study Intravoxel incoherent motion Crohn's disease medicine.diagnostic_test business.industry Ultrasound Magnetic resonance imaging General Medicine Blood flow Middle Aged medicine.disease Magnetic Resonance Imaging Perfusion Diffusion Magnetic Resonance Imaging ROC Curve 030211 gastroenterology & hepatology Female Radiology business Nuclear medicine |
| Zdroj: | European radiology. 29(2) |
| ISSN: | 1432-1084 |
| Popis: | To quantify intravoxel incoherent motion (IVIM)-DWI and dynamic contrast-enhanced (DCE)-MRI parameters in normal and abnormal ileal segments in Crohn’s disease (CD) patients and to assess the association of these parameters with clinical and MRI-based measurements of CD activity. In this prospective study, 27 CD patients (M/F 18/9, mean age 42 years) underwent MR enterography, including IVIM-DWI and DCE-MRI. IVIM-DWI and DCE-MRI parameters were quantified in normal and abnormal small bowel segments, the latter identified by the presence of inflammatory changes. MRI parameter differences between normal and abnormal bowel were tested using Wilcoxon signed-rank tests. IVIM-DWI and DCE-MRI parameters were correlated with clinical data (C-reactive protein, Harvey-Bradshaw Index), conventional MRI parameters (wall thickness, length of involvement) and MRI activity scores (MaRIA, Clermont). Diagnostic performance of (combined) parameters for differentiation between normal and abnormal bowel was determined using ROC analysis. The DCE-MRI parameters peak concentration Cpeak, upslope, area-under-the-curve at 60s (AUC60), Ktrans and ve were significantly increased (p 0.105). DCE-MRI parameters exhibited multiple significant correlations with wall thickness (Cpeak, upslope, AUC60, Ktrans; r range 0.431–0.664, p |
| Databáze: | OpenAIRE |
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