Inverse Levels of Adiponectin in Type 1 and Type 2 Diabetes Are in Accordance with the State of Albuminuria
Autor: | Dubravka Jurisic Erzen, Spomenka Ljubić, Ante Piljac, Branko Novak, Anamarija Jazbec, Neva Brkljacic, Marijana Vučić Lovrenčić, Martina Tomić, Snjezana Kastelan |
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Jazyk: | angličtina |
Rok vydání: | 2015 |
Předmět: |
medicine.medical_specialty
animal structures Article Subject Endocrinology Diabetes and Metabolism Renal function 030209 endocrinology & metabolism adiponectin albuminuria diabetes mellitus Type 2 diabetes 030204 cardiovascular system & hematology lcsh:Diseases of the endocrine glands. Clinical endocrinology Diabetic nephropathy 03 medical and health sciences 0302 clinical medicine Endocrinology Diabetes mellitus Internal medicine medicine Type 1 diabetes lcsh:RC648-665 Adiponectin Endocrine and Autonomic Systems business.industry medicine.disease Albuminuria Metabolic syndrome medicine.symptom business hormones hormone substitutes and hormone antagonists Research Article |
Zdroj: | International Journal of Endocrinology, Vol 2015 (2015) International Journal of Endocrinology |
ISSN: | 1687-8345 1687-8337 |
Popis: | Aims.To investigate the behaviour of adiponectin (ApN) in patients with type 1 and type 2 diabetic nephropathy.Methods.ApN and inflammatory and other markers of the metabolic syndrome were compared across diabetes types, albumin excretion rate (AER), and creatinine clearance (CrCl) categories in 219 type 1 and type 2 diabetic patients.Results.Significant differences among ApN levels according to AER were found in both types of diabetes (F=8.45,df=2,P<0.001). With the progression of albuminuria, ApN increased in type 1 and decreased in type 2 diabetes. Patients with decreased CrCl had higher ApN levels than those with normal CrCl in either type of diabetes (F=12.7,df=1,P<0.001). The best model for ApN (R2=0.9002) obtained from stepwise regression in type 1 diabetes included CrCl, BMI, WBC, CRP, and age, while in type 2 diabetes (R2=0.2882) it included ppPG, LDL, and UA.Conclusion.ApN behaved differently in relation to albuminuria, increasing with its progression in type 1 diabetes and decreasing in type 2 diabetes. It was however increased in the subgroups with decreased CrCl in both types of diabetes. Albuminuria seems to be more important than renal insufficiency in the definition of ApN levels in type 1 and type 2 diabetes. |
Databáze: | OpenAIRE |
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