Anti-inflammatory effects of IL-4 and IL-10 on human polymorphonuclear leukocytes
| Autor: | Young Hoon Yoon, Sung Woo Lee, In Chul Jung, Be An Lee, Sung Hyuk Choi, Su Jin Kim, Chul Kyu Moon, Sungwoo Moon, Chung Min Chun, Jun-Dong Moon, Yun Sik Hong |
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| Jazyk: | angličtina |
| Rok vydání: | 2002 |
| Předmět: |
Intracellular Fluid
Neutrophils Inflammation Biology chemistry.chemical_compound Mediator medicine Humans Interleukin 8 Interleukin 4 Cells Cultured Tumor Necrosis Factor-alpha Interleukin-8 hemic and immune systems General Medicine Hydrogen Peroxide N-Formylmethionine leucyl-phenylalanine N-Formylmethionine Interleukin-10 N-Formylmethionine Leucyl-Phenylalanine Interleukin 10 chemistry Immunology Tumor necrosis factor alpha Interleukin-4 medicine.symptom Research Article |
| Zdroj: | Journal of Korean Medical Science |
| ISSN: | 1598-6357 1011-8934 |
| Popis: | Inflammatory responses are strictly regulated by coordination of pro-inflammatory and anti-inflammatory mediators. Interleukin-4 (IL-4) and interleukin-10 (IL-10) have typically the biologic anti-inflammatory effects on monocytes, but uncertain effects on polymorphonuclear leukocytes (PMNs). The PMNs are the first line of cellular response for host defense during acute inflammation. To modify hyper-inflammatory reaction with biologic anti-inflammatory mediators, we have determined the biologic anti-inflammatory activities of IL-4 and IL-10 on human PMNs. Human PMNs were pretreated with IL-4 or IL-10 and then stimulated with formyl methionyl leucyl phenylalanine (fMLP) for times indicated. The level of H2O2, interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-alpha) were determined in the each cell free supernatants. fMLP plays the role of a typical pro-inflammatory agent and, at least in determined conditions, down-regulated TNF release. IL-4 acts as an anti-inflammatory mediator but IL-10 did not show its anti-inflammatory activities on fMLP-stimulated human PMNs. IL-4 and IL-10 have different anti-inflammatory mechanisms. Perhaps, IL-10 needs co-factors to act as an anti-inflammatory mediator. |
| Databáze: | OpenAIRE |
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