Oxidatively modified LDL particles in the human placenta in early and late onset intrauterine growth restriction

Autor: Ulrich Pecks, Berthold Huppertz, Nicolai Maass, Werner Rath, K. Sosnowsky, R. Caspers, H.-J. Thiesen, B. Ziems
Rok vydání: 2013
Předmět:
Male
Placenta
Intrauterine growth restriction
Oligohydramnios
medicine.disease_cause
Severity of Illness Index
Cohort Studies
Fetal Development
chemistry.chemical_compound
Pre-Eclampsia
Pregnancy
Prenatal Diagnosis
Medicine
reproductive and urinary physiology
Ultrasonography
Fetal Growth Retardation
Obstetrics and Gynecology
Gestational age
female genital diseases and pregnancy complications
Up-Regulation
Lipoproteins
LDL
medicine.anatomical_structure
embryonic structures
Premature Birth
Female
lipids (amino acids
peptides
and proteins)
Adult
congenital
hereditary
and neonatal diseases and abnormalities
medicine.medical_specialty
Young Adult
Internal medicine
Humans
Fetus
Cesarean Section
business.industry
Cholesterol
Cholesterol
HDL
Infant
Newborn
medicine.disease
Placentation
Oxidative Stress
Endocrinology
Reproductive Medicine
chemistry
business
Oxidative stress
Developmental Biology
Zdroj: Placenta. 34:1142-1149
ISSN: 0143-4004
DOI: 10.1016/j.placenta.2013.10.006
Popis: Reduced serum LDL concentrations have been observed in pregnancies complicated by intrauterine growth restriction (IUGR) as compared to healthy pregnant women. Since increased oxidative stress has been suggested to play a major role in IUGR we now hypothesized that the lower LDL concentrations are accompanied by an accumulation of oxidized LDLs in the placenta.Fifteen placentas of near term and preterm born IUGR, and a gestational age matched control group (CTRL n = 15) were analyzed. Placental minimal modified LDL and fully oxidized LDL particles were measured by ELISA, and by immunohistochemistry, and were related to maternal and fetal serum lipid profiles.We found fully oxidized LDL but not minimal modified LDL being increased in the preterm subgroup of IUGR (n = 10) as compared to preterm CTRL (n = 10; p0.05). An increased staining intensity of trophoblasts in preterm IUGR subjects as compared to preterm CTRL has been confirmed by immunohistochemistry (p0.05). No difference could be found between the term groups (n = 5 each). Correlation analysis revealed an inverse relationship of maternal LDL (ρ = −0.49, p = 0.03) and fetal HDL cholesterol (ρ = −0.46, p = 0.04) with placental fully oxidized LDL particle concentration within preterms.IUGR is a heterogeneous entity. Different pathomechanisms seem to underlie the disease in preterm and term subjects with oxidation of LDL within the placenta possibly taking place in preterm IUGRs.We conclude that the reduced maternal LDL cholesterol concentration in IUGR pregnancies is attributed to increased accumulation of oxidized LDL particles within the placenta at least in early onset IUGR
Databáze: OpenAIRE
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