Concise Approach to Novel Isothiazolidinone Phosphotyrosine Mimetics: Microwave-Assisted Addition of Bisulfite to Activated Olefins
| Autor: | Matthew L. Crawley, Erin McLaughlin, Andrew P. Combs, Wenyu Zhu |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Molecular Structure
Molecular Mimicry Organic Chemistry General Medicine Protein tyrosine phosphatase Alkenes Biochemistry Microwave assisted Combinatorial chemistry Styrene Bisulfite Thiazoles chemistry.chemical_compound chemistry Organic chemistry Sulfites Isothiazolidinone Physical and Theoretical Chemistry Microwaves Phosphotyrosine |
| Zdroj: | Organic Letters. 7:5067-5069 |
| ISSN: | 1523-7052 1523-7060 |
| DOI: | 10.1021/ol052076b |
| Popis: | [reaction: see text] A novel and efficient synthesis of isothiazolidinone protein tyrosine phosphatase mimetics is presented. A practical, regiospecific microwave-assisted addition of bisulfite to activated olefins, including unprecedented reactions with styrene derivatives, is highlighted. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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