Efficacy and safety of rituximab in autoimmune pancreatitis type 1: our experiences and systematic review of the literature
| Autor: | Wiktor Rutkowski, Nikola Panic, Miroslav Vujasinovic, Lara Dani, Sara Nikolic, J-Matthias Löhr, Corinna Steiner, Elina Sofia Hintikka, Aleksandra Hedström |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Latent tuberculosis business.industry Autoimmune Pancreatitis Medical record Gastroenterology Antineoplastic Agents medicine.disease Pancreatitis Refractory Internal medicine medicine Humans IgG4-related disease Rituximab business Adverse effect Retrospective Studies medicine.drug Autoimmune pancreatitis |
| Zdroj: | Scandinavian Journal of Gastroenterology. 56:1355-1362 |
| ISSN: | 1502-7708 0036-5521 |
| Popis: | Introduction Autoimmune pancreatitis (AIP) is a special form of pancreatitis that responds well to glucocorticoid (GC) treatment. Relapses of AIP are common. The anti-CD20 antibody rituximab (RTX) has shown promising results in GC refractory cases, but long-term data are scarce. The study aims to determine the clinical and imaging response to RTX and summarize the existing data on RTX therapy in patients with AIP type 1 in the literature. Patients and methods Retrospective analysis of electronic medical records was conducted. Additionally, we conducted a systematic review of the literature concerning RTX use in AIP type 1. Results Twelve (11.7%) of 103 patients with AIP type 1 were treated with RTX during the study period: eight (66.7%) achieved complete and four (33.3%) partial remission. RTX was discontinued in one patient who developed fever and reactivation of latent tuberculosis. None of the remaining 11 patients relapsed during a median follow-up of 17 months. No significant differences were detected in baseline clinical characteristics or history of relapse between the patients who obtained complete and partial remission. Altogether, eight studies with 110 AIP type-1 patients treated with RTX were analyzed. Adverse effects ranged from 11-43% and the relapse-free period during follow-up (range 2-173 months) ranged from 38-94%. Conclusions Our results confirm that RTX is efficacious in the treatment of AIP type 1 by inducing remission and preventing relapse. In addition, there are few adverse effects of the treatment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|