Prospective study of increased platelet membrane fluidity as a risk factor for Alzheimer's disease: results at 5 years
| Autor: | J Moossy, A. J. Martinez, Ivana Teply, Winwood E, Trey Sunderland, Huff Fj, George S. Zubenko |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Blood Platelets Male Oncology medicine.medical_specialty Pathology Membrane Fluidity Disease Asymptomatic Central nervous system disease Degenerative disease Alzheimer Disease Risk Factors Internal medicine medicine Humans Family Longitudinal Studies Prospective Studies Family history Risk factor Prospective cohort study Aged business.industry Incidence Age Factors Middle Aged medicine.disease Psychiatry and Mental health Female medicine.symptom Alzheimer's disease business Biomarkers |
| Zdroj: | American Journal of Psychiatry. 153:420-423 |
| ISSN: | 1535-7228 0002-953X |
| Popis: | Objective : The primary goal of this study was to evaluate increased platelet membrane fluidity as a putative risk factor for Alzheimer's disease. Method : This report describes the initial results of a prospective, longitudinal study of 330 initially asymptomatic, first-degree relatives of probands with Alzheimer's disease. Results : Five incident cases of Alzheimer's disease were detected during the first 1,582 subject-years of the follow-up period. The age-specific incidence of Alzheimer's disease was several-fold higher than corresponding figures that were obtained in two prospective community studies. Most important, both age and increased platelet membrane fluidity made significant independent contributions to the risk of developing Alzheimer's disease. Conclusions : These results validate age and a family history of Alzheimer's disease as risk factors for this disorder and provide the first prospective evidence of increased platelet membrane fluidity as a biological risk factor for Alzheimer's disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|