Body size throughout the life-course and incident benign prostatic hyperplasia-related outcomes and nocturia

Autor: Saira Khan, Lawrence R. Ragard, Ratna Pakpahan, Gerald L. Andriole, Benjamin N. Breyer, Siobhan Sutcliffe, Kathleen Y. Wolin, Jerome Mabie, Robert L. Grubb, Graham A. Colditz
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Urologic Diseases
Male
medicine.medical_specialty
Aging
Urology
Benign Prostatic Hyperplasia (BPH)
Clinical Sciences
PLCO
030232 urology & nephrology
Prostatic Hyperplasia
Overweight
urologic and male genital diseases
lcsh:RC870-923
Prostate volume
03 medical and health sciences
Prostate cancer
0302 clinical medicine
Clinical Research
Internal medicine
medicine
Nocturia
Humans
Obesity
Metabolic and endocrine
Nutrition
Cancer
Benign Prostatic Hyperplasia
business.industry
Prostate Cancer
Prevention
Weight change
Age Factors
General Medicine
Body size
Middle Aged
Urology & Nephrology
medicine.disease
lcsh:Diseases of the genitourinary system. Urology
Confidence interval
Reproductive Medicine
030220 oncology & carcinogenesis
Relative risk
Benign prostatic hyperplasia (BPH)
medicine.symptom
business
Research Article
Zdroj: BMC Urology, Vol 21, Iss 1, Pp 1-13 (2021)
BMC urology, vol 21, iss 1
BMC Urology
ISSN: 1471-2490
Popis: Background Existing evidence suggests that there is an association between body size and prevalent Benign Prostatic Hyperplasia (BPH)-related outcomes and nocturia. However, there is limited evidence on the association between body size throughout the life-course and incident BPH-related outcomes. Methods Our study population consisted of men without histories of prostate cancer, BPH-related outcomes, or nocturia in the intervention arm of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) (n = 4710). Associations for body size in early- (age 20), mid- (age 50) and late-life (age ≥ 55, mean age 60.7 years) and weight change with incident BPH-related outcomes (including self-reported nocturia and physician diagnosis of BPH, digital rectal examination-estimated prostate volume ≥ 30 cc, and prostate-specific antigen [PSA] concentration > 1.4 ng/mL) were examined using Poisson regression with robust variance estimation. Results Men who were obese in late-life were 25% more likely to report nocturia (Relative Risk (RR): 1.25, 95% Confidence Interval (CI): 1.11–1.40; p-trendfor continuous BMI overweight: 1.13, 95% CI 1.07–1.21; RRobese: 1.10, 95% CI 1.02–1.19; p-trendfor continuous BMI = 0.017) as compared to normal weight men. Obesity at ages 20 and 50 was similarly associated with both nocturia and prostate volume ≥ 30 cc. Considering trajectories of body size, men who were normal weight at age 20 and became overweight or obese by later-life had increased risks of nocturia (RRnormal to overweight: 1.09, 95% CI 0.98–1.22; RRnormal to obese: 1.28, 95% CI 1.10–1.47) and a prostate volume ≥ 30 cc (RRnormal to overweight: 1.12, 95% CI 1.05–1.20). Too few men were obese early in life to examine the independent effect of early-life body size. Later-life body size modified the association between physical activity and nocturia. Conclusions We found that later-life body size, independent of early-life body size, was associated with adverse BPH outcomes, suggesting that interventions to reduce body size even late in life can potentially reduce the burden of BPH-related outcomes and nocturia.
Databáze: OpenAIRE
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