Corrected coronary opacification decrease from coronary computed tomography angiography: Validation with quantitative 13N-ammonia positron emission tomography
| Autor: | Philipp A. Kaufmann, Olivier F. Clerc, Oliver Gaemperli, Luis Moritz Neumeier, Michael Messerli, Christoph Gräni, Aju P. Pazhenkottil, Catherine Gebhard, Mathias Possner, Dominik C. Benz, Ronny R. Buechel, Paola Ferro |
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| Přispěvatelé: | University of Zurich, Buechel, Ronny R |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Computed Tomography Angiography Lumen (anatomy) 610 Medicine & health Constriction Pathologic 030204 cardiovascular system & hematology 2705 Cardiology and Cardiovascular Medicine 030218 nuclear medicine & medical imaging Lesion 03 medical and health sciences Myocardial perfusion imaging 0302 clinical medicine Predictive Value of Tests medicine.artery Internal medicine medicine Humans 2741 Radiology Nuclear Medicine and Imaging Radiology Nuclear Medicine and imaging Aorta Aged Retrospective Studies Aged 80 and over quantitative PET myocardial perfusion imaging Nitrogen Radioisotopes medicine.diagnostic_test business.industry Coronary computed tomography angiography Coronary Stenosis Myocardial Perfusion Imaging Reproducibility of Results Blood flow 10181 Clinic for Nuclear Medicine Middle Aged medicine.disease Stenosis ROC Curve Positron emission tomography Positron-Emission Tomography Cardiology Female medicine.symptom Cardiology and Cardiovascular Medicine business Corrected coronary opacification relative flow reserve |
| DOI: | 10.5167/uzh-138447 |
| Popis: | To assess the functional relevance of a coronary artery stenosis, corrected coronary opacification (CCO) decrease derived from coronary computed tomography angiography (CCTA) has been proposed. The present study aims at validating CCO decrease with quantitative 13N-ammonia positron emission tomography (PET) myocardial perfusion imaging (MPI). This retrospective study consists of 39 patients who underwent hybrid CCTA/PET-MPI. From CCTA, attenuation in the coronary lumen was measured before and after a stenosis and corrected to the aorta to calculate CCO and its decrease. Relative flow reserve (RFR) was calculated by dividing the stress myocardial blood flow (MBF) of a vessel territory subtended by a stenotic coronary by the stress MBF of the reference territories without stenoses. RFR was abnormal in 11 vessel territories (27%). CCO decrease yielded a sensitivity, specificity, negative predictive value, positive predictive value, and accuracy for prediction of an abnormal RFR of 73%, 70%, 88%, 47%, and 70%, respectively. CCTA-derived CCO decrease has moderate diagnostic accuracy to predict an abnormal RFR in PET-MPI. However, its high negative predictive value to rule out functional relevance of a given lesion may confer clinical implications in the diagnostic work-up of patients with a coronary stenosis. |
| Databáze: | OpenAIRE |
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