Influence of dietary iron levels on hepatic drug metabolism in vivo and in vitro in the rat
| Autor: | G.C. Becking |
|---|---|
| Rok vydání: | 1972 |
| Předmět: |
Male
medicine.medical_specialty Pentobarbital Iron Cytochrome c Group In Vitro Techniques Biology Biochemistry Hemoglobins Cytochrome P-450 Enzyme System In vivo Internal medicine medicine Animals Aminopyrine Cytochrome Reductases Pharmacology Anemia Hypochromic Aniline Compounds Body Weight Proteins Iron deficiency Metabolism medicine.disease In vitro Diet Rats Endocrinology Hematocrit Liver Phenobarbital Microsomes Liver Microsome Hemoglobin Oxidoreductases NADP Drug metabolism Half-Life medicine.drug |
| Zdroj: | Biochemical Pharmacology. 21:1585-1593 |
| ISSN: | 0006-2952 |
| DOI: | 10.1016/0006-2952(72)90308-5 |
| Popis: | Rats fed an iron-deficient diet for 18 days showed a marked increase in the metabolism in vitro of aniline and after 25 days both the metabolism in vitro and in vivo of aniline was increased. Aminopyrine metabolism in vivo and in vitro was also markedly stimulated in iron-deficient rats but only after hemoglobin levels had decreased to approximately 50 per cent of control. Pentobarbital metabolism in vivo (plasma halflife) and in vitro was not altered in iron deficiency, although deficient animals did exhibit longer sleeping times than control animals. Microsomal cytochrome c reductase activity was increased during iron deficiency but only after a large decrease in hemoglobin concentration had occurred. No alteration in the microsomal cytochromes b 5 or P-450 was noted. All hematological and biochemical lesions were completely ameliorated by refeeding iron-deficient rats the iron-containing control diet. No apparent deleterious effect on drug metabolism was noted after feeding a diet containing 1.5 times the normal iron content. |
| Databáze: | OpenAIRE |
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