Application of modern neuroimaging technology in the diagnosis and study of Alzheimer's disease
| Autor: | Hua Bai, Hua-Bo Han, Hong-Mei Zeng, Qifang Zhang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
brain Hippocampus Review alzheimer’s disease behavior cognitive impairment fluorodeoxyglucose memory neurological function structural magnetic resonance imaging translocator protein lcsh:RC346-429 03 medical and health sciences 0302 clinical medicine Nuclear magnetic resonance Developmental Neuroscience Neuroimaging Medicine Positron emission lcsh:Neurology. Diseases of the nervous system Fluorodeoxyglucose medicine.diagnostic_test business.industry Magnetic resonance imaging Alzheimer's disease Entorhinal cortex equipment and supplies 030104 developmental biology Differential diagnosis business Functional magnetic resonance imaging human activities 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Neural Regeneration Research, Vol 16, Iss 1, Pp 73-79 (2021) Neural Regeneration Research |
| ISSN: | 1673-5374 |
| Popis: | Neurological abnormalities identified via neuroimaging are common in patients with Alzheimer’s disease. However, it is not yet possible to easily detect these abnormalities using head computed tomography in the early stages of the disease. In this review, we evaluated the ways in which modern imaging techniques such as positron emission computed tomography, single photon emission tomography, magnetic resonance spectrum imaging, structural magnetic resonance imaging, magnetic resonance diffusion tensor imaging, magnetic resonance perfusion weighted imaging, magnetic resonance sensitive weighted imaging, and functional magnetic resonance imaging have revealed specific changes not only in brain structure, but also in brain function in Alzheimer’s disease patients. The reviewed literature indicated that decreased fluorodeoxyglucose metabolism in the temporal and parietal lobes of Alzheimer’s disease patients is frequently observed via positron emission computed tomography. Furthermore, patients with Alzheimer’s disease often show a decreased N-acetylaspartic acid/creatine ratio and an increased myoinositol/creatine ratio revealed via magnetic resonance imaging. Atrophy of the entorhinal cortex, hippocampus, and posterior cingulate gyrus can be detected early using structural magnetic resonance imaging. Magnetic resonance sensitive weighted imaging can show small bleeds and abnormal iron metabolism. Task-related functional magnetic resonance imaging can display brain function activity through cerebral blood oxygenation. Resting functional magnetic resonance imaging can display the functional connection between brain neural networks. These are helpful for the differential diagnosis and experimental study of Alzheimer’s disease, and are valuable for exploring the pathogenesis of Alzheimer’s disease. |
| Databáze: | OpenAIRE |
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