Cdx2initiates histodifferentiation of the midgut endoderm
| Autor: | Felix Beck, Emma J. Stringer, Catrin Pritchard |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Mesoderm animal structures Sox2 Biophysics Morphogenesis Mice Transgenic Biology Biochemistry Mice Structural Biology HMGB Proteins Genetics medicine Animals CDX2 Transcription Factor Intestinal Mucosa CDX2 Molecular Biology Homeodomain Proteins SOXB1 Transcription Factors Gut histodifferentiation Endoderm Stomach digestive oral and skin physiology Midgut Embryo Cell Biology Embryo Mammalian Phenotype Molecular biology Mice Mutant Strains digestive system diseases DNA-Binding Proteins Intestines medicine.anatomical_structure Gastric Mucosa Cdx2 embryonic structures Female Haploinsufficiency Barx1 Transcription Factors |
| Zdroj: | FEBS Letters. 582:2555-2560 |
| ISSN: | 0014-5793 |
| DOI: | 10.1016/j.febslet.2008.06.024 |
| Popis: | Null mutation or haploinsufficiency of Cdx2 results in the development of heterotopic lesions with a gastric phenotype in the midgut endoderm. Conversely transgenic expression of Cdx2 in the stomach causes the endoderm to differentiate into intestinal-type mucosa. We demonstrate that the mesoderm adjacent to intestinal heterotopic areas expresses stomach specific Barx1 while the surrounding mesoderm is Barx1 negative. We conclude that the initiation of gut histodifferentiation lies in the endodermal expression of Cdx2 and that endodermal/mesodermal cross-talk involving Barx1 with appropriate feedback loops results in the development of the postnatal gut phenotype. |
| Databáze: | OpenAIRE |
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