A COMPARISON OF THE EARLY METABOLIC EFFECTS OF TRIIODOTHYRONINE AND THYROTROPIC HORMONE IN MAN*
| Autor: | Brian F. Good, J. S. Charnock, Basil S. Hetzel |
|---|---|
| Rok vydání: | 1960 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Endocrinology Diabetes and Metabolism Urinary system medicine.medical_treatment Clinical Biochemistry Thyrotropin Biochemistry Endocrinology Pituitary Hormones Anterior Internal medicine medicine Humans Thyrotropin-Releasing Hormone Saline Triiodothyronine business.industry Biochemistry (medical) Thyroid Pulse pressure medicine.anatomical_structure Basal metabolic rate business Intramuscular injection Hormone |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 20:556-568 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem-20-4-556 |
| Popis: | The early metabolic effects of sodium l-triiodothyronine (T3) and thyrotropic hormone (TSH) were compared within an eight-hour period. Observations were made on 5 healthy volunteer male medical students on each of three occasions after fasting overnight. Each student received TSH (0.44 unit of Thytropar per Kg.) intramuscularly; T3 (0.5 or 1.0 mg.) intravenously as a single dose; and, as a control, intravenous or intramuscular saline in an amount similar to that administered with the TSH or T3. The subjects lay recumbent, dozing and reading at intervals over the eight-hour period. A significantly greater rise in the basal metabolic rate was noted following TSH than following T3 (0.5 or 1.0 mg.). This rise was accompanied by increases in pulse rate and pulse pressure—which were not observed following T3. T3, however, produced a significant increase in the levels of plasma and urinary inorganic phosphate— which was not observed following TSH. The early metabolic effect of TSH was significantly less... |
| Databáze: | OpenAIRE |
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