Genome Scan Meta-Analysis of Schizophrenia and Bipolar Disorder, Part II: Schizophrenia
| Autor: | Andrew McQuillin, Anne S. Bassett, C. Robert Cloninger, Wolfgang Maier, Kenneth S. Kendler, Eva Lindholm, Leena Peltonen, William Byerley, Richard E. Straub, Stylianos E. Antonarakis, Gerald Nestadt, Ann E. Pulver, David L. Garver, Linda M. Brzustowicz, Nigel Williams, Hugh Gurling, F. Anthony O'Neill, Lynn E. DeLisi, Jouko Lönnqvist, Tómas Helgason, Charles A. Kaufmann, Jean-Louis Blouin, Stephen V. Faraone, Jill M. Harkavy-Friedman, Hannes Petursson, Hans W. Moises, Cathryn M. Lewis, Michael Conlon O'Donovan, Jeremy M. Silverman, Elena Jazin, Robin Sherrington, Lesley H. Wise, Douglas F. Levinson, Tiina Paunio, Ming T. Tsuang, Bryan J. Mowry, Thordur Sigmundsson, Jon Brynjolfson, Sarah H. Shaw, Tómas Zoega, Iiris Hovatta, Jesper Ekelund, Dragan M. Svrakic, Gursharan Kalsi, Michael John Owen, Sibylle G. Schwab, Andrea Mesén, Jennifer A. Holcomb, Raymond R. Crowe, Dolores Malaspina, Dermot Walsh, Hilary Coon, Dieter B. Wildenauer |
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| Jazyk: | angličtina |
| Předmět: |
Schizophrenia/ genetics
Bipolar Disorder Genotype Genome Scan Biology Bipolar Disorder/ genetics 03 medical and health sciences Permutation 0302 clinical medicine Genetic linkage medicine Genetics Humans Genetics(clinical) Genetics (clinical) 030304 developmental biology Linkage (software) ddc:616 0303 health sciences Genome Human Articles Heritability medicine.disease Sample size determination Schizophrenia Meta-analysis 030217 neurology & neurosurgery |
| Zdroj: | American Journal of Human Genetics, Vol. 73, No 1 (2003) pp. 34-48 |
| ISSN: | 0002-9297 |
| DOI: | 10.1086/376549 |
| Popis: | Schizophrenia is a common disorder with high heritability and a 10-fold increase in risk to siblings of probands. Replication has been inconsistent for reports of significant genetic linkage. To assess evidence for linkage across studies, rank-based genome scan meta-analysis (GSMA) was applied to data from 20 schizophrenia genome scans. Each marker for each scan was assigned to 1 of 120 30-cM bins, with the bins ranked by linkage scores (1 = most significant) and the ranks averaged across studies (Ravg) and then weighted for sample size (\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \setlength{\oddsidemargin}{-69pt} \begin{document} \begin{equation*}\sqrt{N[affected cases]}\end{equation*}\end{document}). A permutation test was used to compute the probability of observing, by chance, each bin’s average rank (PAvgRnk) or of observing it for a bin with the same place (first, second, etc.) in the order of average ranks in each permutation (Pord). The GSMA produced significant genomewide evidence for linkage on chromosome 2q (PAvgRnk |
| Databáze: | OpenAIRE |
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