Popis: |
Background. Urinary Tract Infections (UTIs) are among most common infections in humans. The vast majority are caused by Escherichia coli, occasionally responsible for severe clinical manifestations. Although the species frequently adheres and colonizes the bladder mucosa, its reservoir is the host gastrointestinal tract. Therefore, the study was designed to evaluate genomic features for niche adaptation of urinary and gastrointestinal strains of E. coli by data mining approach. Results. In the E. coli strains, the repertoire of genes was higher than those found in previous studies, and the majority of genes associated to primary metabolism did not depend of bacteria niche, with exception of cell cycle-division, cell motility and secondary metabolite metabolism. Urinary tract isolates of E. coli had great density of virulence and resistance genes carried by prophages. Conclusion. The urinary and gastrointestinal strains of E. coli evaluated in the study presented an open pan-genome, with groups of functional annotation genes associated to specific niches. In addition, gastrointestinal isolates of E. coli were demonstrated as important reservoir of resistance genes. |