MRI and CBCT for lymph node identification and registration in patients with NSCLC undergoing radical radiotherapy
| Autor: | Cynthia L. Eccles, J. Parker, John Rodgers, Robert Chuter, Marcel van Herk, Rosie Hales, S. Brown, Michael Dubec, Lee Whiteside, Corinne Faivre-Finn, David Cobben |
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| Rok vydání: | 2021 |
| Předmět: |
Lung Neoplasms
Image quality medicine.medical_treatment Locally advanced Image registration 030218 nuclear medicine & medical imaging 03 medical and health sciences Visual grading 0302 clinical medicine medicine Humans Radiology Nuclear Medicine and imaging In patient Lymph node business.industry Radiotherapy Planning Computer-Assisted Radical radiotherapy Spiral Cone-Beam Computed Tomography Hematology Cone-Beam Computed Tomography respiratory system Magnetic Resonance Imaging Radiation therapy medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Lymph Nodes Nuclear medicine business Radiotherapy Image-Guided |
| Zdroj: | Radiotherapy and Oncology. 159:112-118 |
| ISSN: | 0167-8140 |
| DOI: | 10.1016/j.radonc.2021.03.015 |
| Popis: | Purpose This study compared MRI to CBCT for the identification and registration of lymph nodes (LN) in patients with locally advanced (LA)-NSCLC, to assess the suitability of targeting LNs in future MR-image guided radiotherapy (MRgRT) workflows. Method Radiotherapy radiographers carried out Visual Grading Analysis (VGA) assessment of image quality, LN registration and graded their confidence in registration for each of the 24 LNs on CBCT and two MR sequences, MR1 (T2w Turbo Spin Echo) and MR2 (T1w DIXON water only image). Results Pre-registration image quality assessment revealed MR1 and MR2 as significantly superior to CBCT in terms of image quality (p ≤ 0.01). No significant differences were noted in interobserver variability for LN registration between CBCT, MR1 and MR2. Observers were more confident in their MR registrations compared to their CBCT based LN registrations (p ≤ 0.02). Summary Interobserver setup correction variability was not found to be significantly different between CBCT and MR. Image quality and registration confidence were found to be superior for MRI sequences. This is a promising step towards MR-guided radiotherapy for the treatment of LA-NSCLC. |
| Databáze: | OpenAIRE |
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