Melatonin metabolite 6-Sulfatoxymelatonin, Cu/Zn superoxide dismutase, oxidized LDL and malondialdehyde in unstable angina
| Autor: | B.K.S. Sastry, K. Shanthi Naidu, K. Vijayasarathy |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Antioxidant medicine.medical_treatment medicine.disease_cause Superoxide dismutase Melatonin chemistry.chemical_compound Malondialdehyde Internal medicine medicine Humans Angina Unstable chemistry.chemical_classification Reactive oxygen species medicine.diagnostic_test biology Superoxide Dismutase Unstable angina business.industry Middle Aged medicine.disease Lipoproteins LDL Endocrinology chemistry biology.protein Female Cardiology and Cardiovascular Medicine Lipid profile business Oxidative stress medicine.drug |
| Zdroj: | International Journal of Cardiology. 144:315-317 |
| ISSN: | 0167-5273 |
| DOI: | 10.1016/j.ijcard.2009.03.004 |
| Popis: | Melatonin, a lypophylic antioxidant, was reported to be low in patients suffering from myocardial infarction, a disease due to coronary atherosclerosis associated with increased reactive oxygen species. Studies carried out till now have shown association of either melatonin or another antioxidant Cu/Zn SOD in patients suffering from coronary artery disease but not both together. Concurrent measurement of these two parameters will reveal the relationship if any in the probable causation of the disease.We estimated the serum malondialdeheyde, oxidized LDL, lipid profile and activity of Cu/Zn superoxide dismutase and the concentration of urinary metabolite of melatonin, 6-Sulfatoxymelatonin in 24 h urine sample collected from 21 patients suffering from unstable angina and 30 control subjects.A statistically significant decrease in urinary melatonin levels (p0.05), serum Cu/Zn SOD (p0.001) along with significant increase in serum oxidized LDL (p0.001), serum malondialdeheyde (p0.01) were observed in patients compared to controls.Our observations indicate that a decreased excretion of 6-Sulfatoxymelatonin may be causally related to a decrease in serum Cu/Zn SOD, an antioxidant, with a consequent increase in serum oxidized LDL, malondialdehyde contributing to the occurrence of the disease. |
| Databáze: | OpenAIRE |
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