Colon 26 Adenocarcinoma (C26)-Induced Cancer Cachexia Impairs Skeletal Muscle Mitochondrial Function and Content
| Autor: | Rachel L. Nosacka, Andrew Judge, Daria Neyroud, Russell T. Hepple |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Voltage-dependent anion channel Cachexia Physiology Colon 26 adenocarcinoma Oxidative phosphorylation Adenocarcinoma Biochemistry Article 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine Internal medicine Cell Line Tumor medicine Animals Muscle Skeletal biology Chemistry Glutamate receptor Skeletal muscle Cancer cachexia Cell Biology Neoplasms Experimental Mitochondrial respiration Mitochondria Muscle Adenosine diphosphate 030104 developmental biology medicine.anatomical_structure Endocrinology Colonic Neoplasms biology.protein 030217 neurology & neurosurgery |
| Popis: | INTRODUCTION. The present study aimed to determine the impact of colon 26 adenocarcinoma (C26)-induced cancer cachexia on skeletal muscle mitochondrial respiration and content. METHODS. Twelve male CD2F1 mice were injected with C26-cells (tumor bearing (TB) group), whereas 12 age-matched mice received PBS vehicle injection (non-tumor bearing (N-TB) group). Mitochondrial respiration was studied in saponin-permeabilized soleus myofibers. RESULTS. TB mice showed lower body weight (~ 20%) as well as lower soleus, gastrocnemius-plantaris complex and tibialis anterior masses versus N-TB mice (p |
| Databáze: | OpenAIRE |
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