X Chromosomes' Shape-Shifting Foreshadows Random Inactivation
| Autor: | Susanna Mlynarczyk-Evans, Sundeep Kalantry, Angela A Andersen, Morgan Royce-Tolland, Mary Kate Alexander, Joost Gribnau, Barbara Panning |
|---|---|
| Přispěvatelé: | Cell biology |
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
DNA Replication
Male RNA Untranslated X Chromosome QH301-705.5 Biology Development Genetics/Genomics/Gene Therapy General Biochemistry Genetics and Molecular Biology X-inactivation 03 medical and health sciences Mice 0302 clinical medicine Chromosome 16 X Chromosome Inactivation Animals Biology (General) X chromosome In Situ Hybridization Fluorescence Cells Cultured Embryonic Stem Cells 030304 developmental biology Genetics 0303 health sciences General Immunology and Microbiology Models Genetic Mosaicism General Neuroscience Barr body Stem Cells Cell Biology Mus (Mouse) Chromosome 4 Chromosome 3 Synopsis XIST Female RNA Long Noncoding Tsix General Agricultural and Biological Sciences 030217 neurology & neurosurgery Research Article |
| Zdroj: | PLoS Biology PLoS Biology (print), 4(6), 906-916. Public Library of Science Mlynarczyk-Evans, Susanna; Royce-Tolland, Morgan; Alexander, Mary Kate; Andersen, Angela A; Kalantry, Sundeep; Gribnau, Joost; et al.(2006). X chromosomes alternate between two states prior to random X-inactivation. PLOS Biology, 4(6), 906-916. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/80v3h4tz PLoS Biology, Vol 4, Iss 6, p e159 (2006) |
| ISSN: | 1545-7885 1544-9173 |
| Popis: | Early in the development of female mammals, one of the two X chromosomes is silenced in half of cells and the other X chromosome is silenced in the remaining half. The basis of this apparent randomness is not understood. We show that before X-inactivation, the two X chromosomes appear to exist in distinct states that correspond to their fates as the active and inactive X chromosomes. Xist and Tsix, noncoding RNAs that control X chromosome fates upon X-inactivation, also determine the states of the X chromosomes prior to X-inactivation. In wild-type ES cells, X chromosomes switch between states; among the progeny of a single cell, a given X chromosome exhibits each state with equal frequency. We propose a model in which the concerted switching of homologous X chromosomes between mutually exclusive future active and future inactive states provides the basis for the apparently random silencing of one X chromosome in female cells. During female mammalian development, one of the two X chromosomes in each cell is inactivated. Prior to X-inactivation, these chromosomes appear to exist in distinct states that correspond to their fates. |
| Databáze: | OpenAIRE |
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