Altered T cell costimulation during chronic hepatitis B infection
| Autor: | Luisa Barboza, Lisbeth Berrueta, Darrell L. Peterson, M Hernández, Leidith Berrueta-Carrillo, Melisa Colmenares, Siham Salmen, Henry Montes |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Antigens Differentiation T-Lymphocyte CD4-Positive T-Lymphocytes CD40 Ligand Immunology Lymphocyte Activation medicine.disease_cause Hepatitis B Chronic Immune system CD28 Antigens Antigen Antigens CD Tetanus Toxoid medicine Humans Lectins C-Type Hepatitis B virus CD40 Ionophores biology Ionomycin CD28 Middle Aged Hepatitis B medicine.disease Hepatitis B Core Antigens Virology Interleukin-10 Interleukin 10 HBcAg biology.protein Cytokines Tetradecanoylphorbol Acetate |
| Zdroj: | Cellular Immunology. 257:61-68 |
| ISSN: | 0008-8749 |
| DOI: | 10.1016/j.cellimm.2009.02.008 |
| Popis: | T-cell response to hepatitis B virus (HBV) is vigorous, polyclonal and multi-specific in patients with acute hepatitis who ultimately clear the virus, whereas it is narrow and inefficient in patients with chronic disease, where inappropriate early activation events could account for viral persistence. We investigated the induction of activation receptors and cytokine production in response to HBcAg and crosslinking of CD28 molecules, in CD4+ cells from a group of chronically infected patients (CIP) and naturally immune subjects (NIS). We demonstrated that CD4+ cells from CIP did not increase levels of CD40L and CD69 following stimulation with HBcAg alone or associated to CD28 crosslinking, in contrast to subjects that resolved the infection (p |
| Databáze: | OpenAIRE |
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