Computerized morphometric assessment of the effect of low-level laser therapy on bone repair: an experimental animal study
| Autor: | Luciana Maria Pedreira Ramalho, Renata Amadei Nicolau, Ruben Weismann, Antonio Luiz Barbosa Pinheiro, Marília Gerhardt de Oliveira, Aurelício Novaes Silva Júnior |
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| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Biomedical Engineering Bone healing Bone and Bones Calcification Physiologic Laser therapy Image Processing Computer-Assisted Medicine Animals Femur Rats Wistar Low level laser therapy Wound Healing business.industry Significant difference Background data Surgical wound Surgery Rats Experimental animal Female Laser Therapy business Nuclear medicine |
| Zdroj: | Journal of clinical laser medicinesurgery. 20(2) |
| ISSN: | 1044-5471 |
| Popis: | The aim of this study was to evaluate morphometrically the amount of newly formed bone after GaAlAs laser irradiation of surgical wounds created in the femur of rats.Low-level laser therapy (LLLT) has been used in several medical specialties because of its biomodulatory effects on different biological tissues. However, LLLT is still controversial because of contradictory reports. This is a direct result of the different methodologies used in these works.In this study, 40 Wistar rats were divided into four groups of 10 animals each: group A (12 sessions, 4.8 J/cm2 per session, observation time of 28 days); group C (three sessions, 4.8 J/cm2 per session, observation time of 7 days). Groups B and D acted as nonirradiated controls. The specimens were routinely processed to wax and cut at 6-microm thickness and stained with HE. For computerized morphometry, Imagelab software was used.Computerized morphometry showed a significant difference between the areas of mineralized bone in groups C and D (p = 0.017). There was no difference between groups A and B (28 days; p = 0.383).It is concluded that, under this experimental condition, LLLT increased bone repair at early bone healing. |
| Databáze: | OpenAIRE |
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