A 3-alkylpyridine-bearing alkaloid exhibits potent antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA) with no detectable resistance

Autor:	Karina M.S. Herrera, Gabriela F.M. Lopes, Michael E. Oliveira, Jaqueline F. Sousa, William G. Lima, Fernanda K. Silva, Júlio C.M. Brito, Ana Júlia P.S. Gomes, Gustavo H.R. Viana, Adriana C. Soares, Jaqueline M.S. Ferreira
Rok vydání:	2021
Předmět:	Methicillin-Resistant Staphylococcus aureus Alkaloids Vancomycin Biofilms Staphylococcus Humans Microbial Sensitivity Tests Staphylococcal Infections Microbiology Anti-Bacterial Agents
Zdroj:	Microbiological research. 261
ISSN:	1618-0623
Popis:	Staphylococcus aureus is a Gram-positive bacterium responsible for a wide variety of infectious diseases, and its methicillin-resistant isolates pose a serious worldwide public health risk. New drugs are urgently needed for the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections. Here, we evaluated the antibacterial activity of five 3-alkyl-pyridinic analogs against MRSA and, of these compounds, compound 6 showed promising antibacterial activity against Staphylococcus with minimum inhibitory concentration (MIC) ranging from 0.98 to 3.9 μgmL
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe3d71e300696f3cf059119bed87abdf https://pubmed.ncbi.nlm.nih.gov/35636092 Zobrazit plný text záznamu Full Text from ScienceDirect