Nitric Oxide Regulates GluA2-Lacking AMPAR Contribution to Synaptic Transmission of CA1 Apical but Not Basal Dendrites
| Autor: | Violetta O. Ivanova, Pavel M. Balaban, Natalia V. Bal |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
hippocampus Hippocampus Stimulation Neurosciences. Biological psychiatry. Neuropsychiatry AMPA receptor Neurotransmission 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine nitric oxide AMPA LTP induction synaptic transmission Receptor Original Research pyramidal neurons Chemistry Long-term potentiation Cell Biology 030104 developmental biology nervous system Synaptic plasticity Biophysics Neuroscience 030217 neurology & neurosurgery RC321-571 |
| Zdroj: | Frontiers in Synaptic Neuroscience Frontiers in Synaptic Neuroscience, Vol 13 (2021) |
| ISSN: | 1663-3563 |
| Popis: | The mechanisms of synaptic plasticity differ in distinct local circuits. In the CA1 region of the hippocampus, the mechanisms of long-term potentiation (LTP) at apical dendrites instratum radiatumand basal dendrites instratum oriensinvolve different molecular cascades. For instance, participation of nitric oxide in LTP induction was shown to be necessary only for apical dendrites. This phenomenon may play a key role in information processing in CA1, and one of the reasons for this difference may be differing synaptic characteristics in these regions. Here, we compared the synaptic responses to stimulation of apical and basal dendrites of CA1 pyramidal neurons and found a difference in the current–voltage characteristics of these inputs, which is presumably due to a distinct contribution of GluA2-lacking AMPA receptors to synaptic transmission. In addition, we obtained data that indicate the presence of these receptors in pyramidal dendrites in bothstratum radiatumandstratum oriens. We also demonstrated that inhibition of NO synthase reduced the contribution of GluA2-lacking AMPA receptors at apical but not basal dendrites, and inhibition of soluble guanylate cyclase did not affect this phenomenon. |
| Databáze: | OpenAIRE |
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