Are oxyphil cells responsible for the ineffectiveness of cinacalcet hydrochloride in haemodialysis patients?
| Autor: | Jacques Rottembourg, Fabrice Menegaux |
|---|---|
| Přispěvatelé: | Service de Néphrologie [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Chirurgie Générale, Viscérale et Endocrinienne [CHU Pitié-Sapêtrière], Service de néphrologie [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU) |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Parathyroidectomy
medicine.medical_specialty Cinacalcet Calcimimetic calcium-sensing receptor medicine.medical_treatment 030232 urology & nephrology Parathyroid hormone [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology 03 medical and health sciences 0302 clinical medicine secondary hyperparathyroidism Internal medicine medicine CKD-Mbd Oxyphil cell (parathyroid) Transplantation business.industry [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism medicine.disease 3. Good health calcimimetic haemodialysis Endocrinology Nephrology Cinacalcet Hydrochloride Secondary hyperparathyroidism Calcium-sensing receptor business chronic kidney disease medicine.drug |
| Zdroj: | Clinical Kidney Journal Clinical Kidney Journal, Oxford University Press, 2019, 12 (3), pp.433-436. ⟨10.1093/ckj/sfy062⟩ |
| ISSN: | 2048-8513 2048-8505 |
| DOI: | 10.1093/ckj/sfy062⟩ |
| Popis: | International audience; Parathyroid glands consist primarily of chief cells. In some cases, the proportion of parathyroid oxyphil cells increases in patients with chronic kidney disease. We describe a case of secondary hyperparathyroidism (SHPT) in a patient treated with haemodialysis who initially received large doses of vitamin D and calcium (Ca) supplements, as well as high doses of cinacalcet hydrochloride (C-HCl), but without any effect on parathyroid hormone levels. Following a successful parathyroidectomy, histopathological examination revealed that two of the parathyroid glands consisted of 40% of oxyphil cells. Oxyphil cells have significantly more Ca-sensing receptors (CaSRs) than chief cells, suggesting that CaSRs are involved in the transdifferentiation of chief cells to oxyphil cells. C-HCl treatment leads to a significant increase in parathyroid oxyphil cell content. This case suggests that C-HCl may induce specific phenotypic alterations in hyperplastic parathyroid glands in patients with severe SHPT. |
| Databáze: | OpenAIRE |
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