Gain-of-function mutation in SCN11A causes itch and affects neurogenic inflammation and muscle function in Scn11a+/L799P mice

Autor: Mieczyslaw Gajda, Matthias Ebbinghaus, Hans-Georg Schaible, Christian A. Hübner, Ingo Kurth, Gisela Segond von Banchet, Volker Adams, Lutz Liebmann, Lorena Tuchscherr
Rok vydání: 2020
Předmět:
Male
0301 basic medicine
Physiology
Sensory Physiology
Social Sciences
Nervous System
Mice
0302 clinical medicine
Skeletal Joints
Animal Cells
Intestine
Small
Medicine and Health Sciences
Psychology
Musculoskeletal System
Neurons
Mammals
Gastrointestinal tract
Neurogenic inflammation
Muscle Weakness
Multidisciplinary
Hand Strength
Nerves
Muscles
Eukaryota
Sciatic Nerve
Sensory Systems
medicine.anatomical_structure
Somatosensory System
Gain of Function Mutation
Vertebrates
Medicine
Sensory Perception
Female
Cellular Types
Anatomy
medicine.symptom
Research Article
Congenital insensitivity to pain
medicine.medical_specialty
Calcitonin Gene-Related Peptide
Movement
Science
Calcitonin gene-related peptide
Muscle Fibers
Rodents
Sciatic Nerves
03 medical and health sciences
Internal medicine
medicine
Animals
Gastrointestinal Transit
Muscle
Skeletal
NAV1.9 Voltage-Gated Sodium Channel
Skeleton
business.industry
Pruritus
Sodium channel
Cognitive Psychology
Organisms
Biology and Life Sciences
Pain Sensation
Muscle weakness
Skeletal muscle
Cell Biology
Skeletal Muscle Fibers
medicine.disease
Small intestine
Mice
Inbred C57BL
030104 developmental biology
Endocrinology
Cellular Neuroscience
Amniotes
Cognitive Science
Perception
business
Zoology
030217 neurology & neurosurgery
Neuroscience
Zdroj: PLoS ONE, Vol 15, Iss 8, p e0237101 (2020)
PLOS ONE 15(8), e0237101 (2020). doi:10.1371/journal.pone.0237101
PLoS ONE
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0237101
Popis: PLoS ONE 15(8), e0237101 (2020). doi:10.1371/journal.pone.0237101
Published by PLOS, San Francisco, California, US
Databáze: OpenAIRE
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