Bis(acetato)bis(1-methyl-4,5-diphenylimidazole)copper(II): preparation, characterization, crystal structure, DNA strand breakage and cytogenetic effect
| Autor: | A. Terzis, Catherine P. Raptopoulou, Spyros P. Perlepes, D.A. Kyriakidis, Evangelos G. Bakalbassis, Sofia Paschalidou, Jerzy Mroziński, Th. Lialiaris, Anastasia A. Pantazaki |
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| Rok vydání: | 1998 |
| Předmět: |
Models
Molecular Guanosine Monophosphate chemistry.chemical_element Antineoplastic Agents Crystal structure Triclinic crystal system Crystallography X-Ray Spectrum Analysis Raman Biochemistry Inorganic Chemistry chemistry.chemical_compound Organometallic Compounds Imidazole Humans Carboxylate Ribonuclease T1 Deoxyribonucleases Type II Site-Specific Ligand Hydrolysis Electron Spin Resonance Spectroscopy DNA Copper Bipyramid Crystallography chemistry Models Chemical DNA supercoil Sister Chromatid Exchange DNA Damage |
| Zdroj: | Journal of inorganic biochemistry. 71(1-2) |
| ISSN: | 0162-0134 |
| Popis: | The preparation, characterization and antitumour properties of the complex [Cu(O 2 CMe) 2 L 2 ] ( 1 ), where L=1-methyl-4,5-diphenylimidazole, are described. The crystal structure of 1 (triclinic, space group , a =6.743(1), b =8.006(1), c =15.898(1) A, α =102.87(1), β =101.10(1), γ =76.76(1)°, Z =1) has been determined ( R =0.0254, R w =0.0275). In the centrosymmetric complex the copper ion is in an essentially square planar environment consisting of two pyridine-type imidazole nitrogen atoms and an oxygen atom from each acetate ligand; the second oxygen atoms of the carboxylate functionalities are involved in weak interactions with the metal completing the coordination to a very distorted tetragonal bipyramid. Complex 1 has been also characterized by elemental analyses, thermal methods, variable-temperature magnetic susceptibility and spectroscopic (IR and far-IR, FT-Raman, UV/VIS, EPR) techniques. The effect of the complex on the in vitro DNA strand breakage was examined. It was found that 1 causes degradation on the linearized pKS DNA, ds and ss DNA. High concentrations of this Cu(II) complex cause scissions on the relaxed and the supercoiled DNA. Furthermore, the in vivo cytogenic effect of 1 was examined on human lymphocyte cells. This study presents indications that 1 could have some relevance in the treatment of tumour cell lines. An orbital interpretation of the interaction of 1 with the DNA bases is proposed. |
| Databáze: | OpenAIRE |
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