A role for the endocannabinoid 2-arachidonoyl-sn-glycerol for social and high-fat food reward in male mice
| Autor: | Dandan Li, Jennifer Daglian, Kwang-Mook Jung, Don Wei, DaYeon Lee, Daniele Piomelli |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Cannabinoid receptor medicine.medical_treatment Monoacylglycerol lipase Male mice Mice Transgenic Hippocampus Article Nucleus Accumbens Mice Random Allocation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Cocaine Receptor Cannabinoid CB1 Reward Conditioning Psychological medicine Animals High-fat reward Social Behavior Receptor Pharmacology musculoskeletal neural and ocular physiology Anandamide Social reward Dietary Fats Endocannabinoid system Monoacylglycerol Lipases 030104 developmental biology nervous system chemistry Biochemistry lipids (amino acids peptides and proteins) Brain stimulation reward Cannabinoid Psychology Neuroscience psychological phenomena and processes 030217 neurology & neurosurgery Endocannabinoids Signal Transduction |
| Zdroj: | Wei, D; Lee, D; Li, D; Daglian, J; Jung, K-M; & Piomelli, D. (2016). A role for the endocannabinoid 2-arachidonoyl-sn-glycerol for social and high-fat food reward in male mice. PSYCHOPHARMACOLOGY, 233(10), 1911-1919. doi: 10.1007/s00213-016-4222-0. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/5c38t9p2 |
| ISSN: | 1432-2072 0033-3158 |
| DOI: | 10.1007/s00213-016-4222-0 |
| Popis: | The endocannabinoid system is an important modulator of brain reward signaling. Investigations have focused on cannabinoid (CB1) receptors, because dissection of specific contributions of individual endocannabinoids has been limited by the available toolset. While we recently described an important role for the endocannabinoid anandamide in the regulation of social reward, it remains to be determined whether the other major endocannabinoid, 2-arachidonoyl-sn-glycerol (2-AG), serves a similar or different function.To study the role of 2-AG in natural reward, we used a transgenic mouse model (MGL-Tg mice) in which forebrain 2-AG levels are selectively reduced. We complemented behavioral analysis with measurements of brain 2-AG levels.We tested male MGL-Tg mice in conditioned place preference (CPP) tasks for high-fat food, social contact, and cocaine. We measured 2-AG content in the brain regions of interest by liquid chromatography/mass spectrometry.Male MGL-Tg mice are impaired in developing CPP for high-fat food and social interaction, but do develop CPP for cocaine. Furthermore, compared to isolated mice, levels of 2-AG in socially stimulated wild-type mice are higher in the nucleus accumbens and ventral hippocampus (183 and 140 % of controls, respectively), but unchanged in the medial prefrontal cortex.The results suggest that reducing 2-AG-mediated endocannabinoid signaling impairs social and high-fat food reward in male mice, and that social stimulation mobilizes 2-AG in key brain regions implicated in the control of motivated behavior. The time course of this response differentiates 2-AG from anandamide, whose role in mediating social reward was previously documented. |
| Databáze: | OpenAIRE |
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