Clinical phenotype and outcome of hepatitis E virus-associated neuralgic amyotrophy
| Autor: | Nassim Kamar, René Gerolami, Jenny Herrod, Jean-Marie Péron, Jacques Izopet, Brendan McLean, David H. Benninger, Baziel G.M. van Engelen, Johannes Hartl, Roland Sahli, P. Ripellino, Mohamed Abdelrahim, Vincent Aubert, Marcus Panning, Rebecca Lissmann, Emanuela Pasi, Hélène Blasco-Perrin, Hafiz Hamad Ashraf, Nan X. Lin, Richard P. Bendall, Richard G. Madden, Shahram Attarian, Nens van Alfen, Jeroen J.J. van Eijk, Sven Pischke, Harry R. Dalton, Bart C. Jacobs, Omar A.B.A.L. Masri, Maria Teresa Giordani, Philippe Colson, Darius Moradpour, Montserrat Fraga, Giorgia Melli, Miriam Fritz, Claudio Gobbi, Thierry Kuntzer, Catherine Jones |
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| Přispěvatelé: | Neurocenter of Southern Switzerland, Ospedale Regionale di Lugano, Centre Hospitalier Universitaire Vaudois [Lausanne] (CHUV), Division of Gastroenterology and Hepatology, Université de Lausanne (UNIL), Génétique Médicale et Génomique Fonctionnelle (GMGF), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre de référence des maladies neuromusculaires et de la SLA, Hôpital de la Timone [CHU - APHM] (TIMONE), Assistance Publique - Hôpitaux de Marseille (APHM), Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, INSB-INSB-Centre National de la Recherche Scientifique (CNRS), Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School [Hannover] (MHH), Bernhard Nocht Institute for Tropical Medicine - Bernhard-Nocht-Institut für Tropenmedizin [Hamburg, Germany] (BNITM), Hepato-gastro-enterology, Toulouse University hospital, Centre de Physiopathologie Toulouse Purpan (CPTP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Département de Néphrologie et Transplantation d'organes, Hôpital de Rangueil, CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse], Université de Lausanne = University of Lausanne (UNIL), Institut des sciences biologiques (INSB-CNRS)-Institut des sciences biologiques (INSB-CNRS)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Département de Néphrologie et Transplantation d'organes [CHU Toulouse], Pôle Urologie - Néphrologie - Dialyse - Transplantations - Brûlés - Chirurgie plastique - Explorations fonctionnelles et physiologiques [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Neurology |
| Rok vydání: | 2017 |
| Předmět: |
Male
Pathology viruses medicine.disease_cause Gastroenterology 0302 clinical medicine Hepatitis E virus Liver Function Tests Medicine Phrenic nerve Brachial Plexus Neuritis Aged 80 and over medicine.diagnostic_test biology virus diseases Middle Aged Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3] Hepatitis E 3. Good health Europe Phenotype Treatment Outcome RNA Viral 030211 gastroenterology & hepatology Female Adult medicine.medical_specialty 03 medical and health sciences Young Adult SDG 3 - Good Health and Well-being Internal medicine Humans Brachial Plexus Hepatitis Antibodies Aged Retrospective Studies business.industry Retrospective cohort study medicine.disease digestive system diseases B900 Immunoglobulin M Immunoglobulin G biology.protein Neurology (clinical) business Liver function tests Brachial plexus 030217 neurology & neurosurgery [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| Zdroj: | Neurology Neurology, American Academy of Neurology, 2017, 89 (9), pp.909-917. ⟨10.1212/WNL.0000000000004297⟩ Neurology, 89, 909-917 Neurology, 2017, 89 (9), pp.909-917. ⟨10.1212/WNL.0000000000004297⟩ Neurology, 89, 9, pp. 909-917 Neurology, 89(9), 909-917. Lippincott Williams & Wilkins |
| ISSN: | 1526-632X 0028-3878 |
| Popis: | Objective:To determine the clinical phenotype and outcome in hepatitis E virus–associated neuralgic amyotrophy (HEV-NA).Methods:Cases of NA were identified in 11 centers from 7 European countries, with retrospective analysis of demographics, clinical/laboratory findings, and treatment and outcome. Cases of HEV-NA were compared with NA cases without evidence of HEV infection.Results:Fifty-seven cases of HEV-NA and 61 NA cases without HEV were studied. Fifty-six of 57 HEV-NA cases were anti-HEV IgM positive; 53/57 were IgG positive. In 38 cases, HEV RNA was recovered from the serum and in 1 from the CSF (all genotype 3). Fifty-one of 57 HEV-NA cases were anicteric; median alanine aminotransferase 259 IU/L (range 12–2,961 IU/L); in 6 cases, liver function tests were normal. HEV-NA cases were more likely to have bilateral involvement (80.0% vs 8.6%, p < 0.001), damage outside the brachial plexus (58.5% vs 10.5%, p < 0.01), including phrenic nerve and lumbosacral plexus injury (25.0% vs 3.5%, p = 0.01, and 26.4% vs 7.0%, p = 0.001), reduced reflexes (p = 0.03), sensory symptoms (p = 0.04) with more extensive damage to the brachial plexus. There was no difference in outcome between the 2 groups at 12 months.Conclusions:Patients with HEV-NA are usually anicteric and have a distinct clinical phenotype, with predominately bilateral asymmetrical involvement of, and more extensive damage to, the brachial plexus. Involvement outside the brachial plexus is more common in HEV-NA. The relationship between HEV and NA is likely to be causal, but is easily overlooked. Patients presenting with NA should be tested for HEV, irrespective of liver function test results. Prospective treatment/outcome studies of HEV-NA are warranted. |
| Databáze: | OpenAIRE |
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