Pleiotropic effects of statins: A focus on cancer
| Autor: | Tayyebeh Madrakian, Shahla Shojaei, Dedmer Schaafsma, Javad Alizadeh, Reza Mahdian, Jakub Rosik, Simone C. da Silva Rosa, Shayan Amiri, Filip Machaj, Stevan Pecic, Saeid Ghavami, Marek J. Łos, Mazaher Ahmadi, Amir A. Zeki |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
rho GTP-Binding Proteins
0301 basic medicine Statin medicine.drug_class medicine.medical_treatment Cancer therapy Antineoplastic Agents Pharmacology 03 medical and health sciences 0302 clinical medicine Prenylation Neoplasms medicine Humans cardiovascular diseases Molecular Biology Cell Proliferation Chemotherapy Molecular Structure business.industry Autophagy nutritional and metabolic diseases Cancer medicine.disease 030104 developmental biology Apoptosis 030220 oncology & carcinogenesis Cancer cell ras Proteins Molecular Medicine Hydroxymethylglutaryl CoA Reductases lipids (amino acids peptides and proteins) Hydroxymethylglutaryl-CoA Reductase Inhibitors business Signal Transduction |
| Zdroj: | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1866:165968 |
| ISSN: | 0925-4439 |
| DOI: | 10.1016/j.bbadis.2020.165968 |
| Popis: | The statin drugs ('statins') potently inhibit hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase by competitively blocking the active site of the enzyme. Statins decrease de novo cholesterol biosynthesis and thereby reduce plasma cholesterol levels. Statins exhibit "pleiotropic" properties that are independent of their lipid-lowering effects. For example, preclinical evidence suggests that statins inhibit tumor growth and induce apoptosis in specific cancer cell types. Furthermore, statins show chemo-sensitizing effects by impairing Ras family GTPase signaling. However, whether statins have clinically meaningful anti-cancer effects remains an area of active investigation. Both preclinical and clinical studies on the potential mechanisms of action of statins in several cancers have been reviewed in the literature. Considering the contradictory data on their efficacy, we present an up-to-date summary of the pleiotropic effects of statins in cancer therapy and review their impact on different malignancies. We also discuss the synergistic anti-cancer effects of statins when combined with other more conventional anti-cancer drugs to highlight areas of potential therapeutic development. |
| Databáze: | OpenAIRE |
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