Long-Term Cerebrospinal Fluid and Blood Lymphocyte Dynamics After Rituximab for Pediatric Opsoclonus-Myoclonus
| Autor: | Elizabeth D. Tate, Anna L. Travelstead, Jerry A. Colliver, Michael R. Pranzatelli |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
Pathology medicine.medical_specialty Time Factors Adolescent T-Lymphocytes T cell Immunology Immunophenotyping Antibodies Monoclonal Murine-Derived Cerebrospinal fluid Antigens CD Neuroblastoma Humans Immunology and Allergy Medicine Child Cells Cultured B cell Cell Proliferation B-Lymphocytes Opsoclonus-Myoclonus Syndrome biology business.industry Antibodies Monoclonal Infant medicine.disease Lymphocyte Subsets medicine.anatomical_structure Child Preschool Monoclonal biology.protein Female Rituximab Antibody business Immunologic Memory Follow-Up Studies medicine.drug |
| Zdroj: | Journal of Clinical Immunology. 30:106-113 |
| ISSN: | 1573-2592 0271-9142 |
| Popis: | Opsoclonus-myoclonus syndrome (OMS) is an autoimmune paraneoplastic disorder characterized by B and T cell abnormalities in cerebrospinal fluid (CSF) and propensity for relapse. The study aim was to assess whether rituximab-induced B cell ablation in CSF outlasts repopulation in blood and if there are changes in other lymphocyte subsets.In 25 children with OMS, the expression of CSF and blood lymphocyte surface antigens was evaluated by flow cytometry before and at intervals after rituximab therapy.The reduction in CSF CD27+ memory, CD38+ activated, CD5+, and other B cell subsets was profound (p0.0001), comparable across groups (-94%), and sustained over 12-18 months despite repopulation in blood. The observed lag in memory B cell pool recovery in the CSF compared to peripheral blood may be clinically relevant. T cell phenotypic changes involved frequency, not absolute counts, and were transient. Co-treatment with IVIg or ACTH did not significantly alter B cell depletion or repletion.These data indicate that rituximab affords long-term protection against CSF B cell expansion in OMS (ClinicalTrials.gov NCT00244361). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink