Acute hypoxic exercise does not alter post-exercise iron metabolism in moderately trained endurance athletes
| Autor: | Christopher J. Gore, Dorine W. Swinkels, Laura A. Garvican-Lewis, Coby M. Laarakkers, Chris R. Abbiss, Andrew Govus, Peter Peeling |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Physiology Iron Hepcidin Oxygen Consumption Hepcidins Intermittent hypoxic training Physiology (medical) Internal medicine Garvican-Lewis Heart rate Garvican medicine Humans Orthopedics and Sports Medicine Hypoxia Exercise Soluble transferrin receptor chemistry.chemical_classification biology Interleukin-6 Transferrin saturation business.industry Iron deficiency Public Health Environmental and Occupational Health General Medicine medicine.disease Ferritin Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11] Endocrinology chemistry Athletes Altitude training Transferrin biology.protein Female business |
| Zdroj: | European Journal of Applied Physiology, 114, 2183-91 European Journal of Applied Physiology, 114, 10, pp. 2183-91 |
| ISSN: | 1439-6319 |
| Popis: | Item does not contain fulltext PURPOSE: This study measured the influence of acute hypoxic exercise on Interleukin-6 (IL-6), hepcidin, and iron biomarkers in athletes. METHODS: In a repeated measures design, 13 moderately trained endurance athletes performed 5 x 4 min intervals at 90 % of their peak oxygen consumption velocity (vVO2peak) in both normoxic [NORM, fraction of inspired oxygen (F IO2) = 0.2093, 15.3 +/- 1.7 km h(-1)] and simulated hypoxic (HYP, F IO2 = 0.1450, 13.2 +/- 1.5 km h(-1)) conditions. Venous blood samples were obtained pre-, post-, and 3 h post-exercise, and analysed for serum hepcidin, IL-6, ferritin, iron, soluble transferrin receptor (sTfR), and transferrin saturation. RESULTS: Peak heart rate was significantly lower in HYP compared with NORM (p = 0.01); however, the rating of perceived exertion was similar between trials (p = 0.24). Ferritin (p = 0.02), transferrin (p = 0.03), and IL-6 (p = 0.01) significantly increased immediately post-exercise in both conditions, but returned to baseline 3 h later. Hepcidin levels significantly increased in both conditions 3 h post-exercise (p = 0.05), with no significant differences between trials. A significant treatment effect was observed between trials for sTfR (p = 0.01), but not iron and transferrin saturation. CONCLUSION: Acute exercise in hypoxia did not influence post-exercise IL-6 production, hepcidin activity or iron metabolism compared with exercise at the same relative intensity in normoxia. Hence, acute exercise performed at the same relative intensity in hypoxia poses no further risk to an athlete's iron status, as compared with exercise in normoxia. |
| Databáze: | OpenAIRE |
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