Investigation of human papillomavirus DNA in colorectal carcinomas and adenomas
| Autor: | Resat Dabak, Taflan Salepci, Dilek Yavuzer, Nimet Karadayi, Huseyin Baloglu, Oya Uygur Bayramiçli |
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| Přispěvatelé: | Maltepe Üniversitesi |
| Rok vydání: | 2010 |
| Předmět: |
Adenoma
Human papillomavirus Cancer Research Pathology medicine.medical_specialty Carcinogenesis Colorectal cancer Uterine Cervical Neoplasms Adenocarcinoma Cervical intraepithelial neoplasia Polymerase Chain Reaction medicine Humans Neoplasm Invasiveness Papillomaviridae Cervical cancer business.industry Papillomavirus Infections HPV infection virus diseases Hematology General Medicine Middle Aged Prognosis Uterine Cervical Dysplasia medicine.disease Adenocarcinoma Mucinous Koilocyte Polymerase chain reaction Colorectal carcinoma Tumor Virus Infections Oncology Case-Control Studies DNA Viral Female Colorectal Neoplasms business Nested polymerase chain reaction |
| Zdroj: | Medical Oncology. 28:127-132 |
| ISSN: | 1559-131X 1357-0560 |
| DOI: | 10.1007/s12032-010-9416-4 |
| Popis: | WOS: 000287756000019 PubMed ID: 20082157 Human papillomavirus (HPV) has been considered to be an etiological agent for anogenital cancers, such as cervical cancer and possibly a subset of cancers of the aerodigestive tract. The aim of the study was to evaluate the presence of human papillomavirus DNA in colorectal carcinomas and adenomas. Formalin-fixed and paraffin-embedded archival tissue samples were used for DNA extraction. One hundred and six colorectal carcinomas and 62 adenomas were screened by nested polymerase chain reaction (PCR) for HPV DNA with a control group of 49 cervical tissues with invasive cervical carcinoma and cervical intraepithelial neoplasia (CIN). In the study group, we did not find HPV DNA positivity in any of all the colorectal carcinomas and adenomas. In the control group with cervical lesions, 34 out of 49 (69.4%) samples were positive for the HPV DNA. These results indicated that there was no correlation between HPV infection and colorectal carcinomas and adenomas. |
| Databáze: | OpenAIRE |
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