Protective influence of Pongamia pinnata (Karanja) on blood ammonia and urea levels in ammonium chloride-induced hyperammonemia: antihyperammonemic effect of the leaf extract
| Autor: | Tamilarasan Manivasagam, Musthafa Mohamed Essa, Perumal Subramanian, K.B. Dakshayani, Ganapathy Suthakar |
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| Rok vydání: | 2005 |
| Předmět: |
Creatinine
Antioxidant General Immunology and Microbiology biology General Neuroscience Health Toxicology and Mutagenesis medicine.medical_treatment Pongamia Biomedical Engineering Hyperammonemia General Medicine medicine.disease biology.organism_classification General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound chemistry Artificial Intelligence medicine Urea Non-protein nitrogen Uric acid Ammonium chloride Food science General Pharmacology Toxicology and Pharmaceutics General Agricultural and Biological Sciences |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1214-0287 1214-021X |
| DOI: | 10.32725/jab.2005.017 |
| Popis: | The present study was undertaken to investigate the antihyperammonemic efficacy of the leaf extract of Pongamia pinnata, an indigenous plant used in Ayurvedic Medicine in India (PPEt), on blood ammonia, plasma urea, uric acid, non-protein nitrogen and serum creatinine in control and ammonium chloride induced hyperammonemic rats. The levels of blood ammonia, circulatory urea, uric acid, non-protein nitrogen and creatinine increased significantly in rats treated with ammonium chloride and decreased significantly in rats treated with PPEt and ammonium chloride. There were no significant changes in the body weights of the experimental animals when compared to controls. The antihyperammonemic effect of PPEt could be attributed to (1) its nephroprotective effect by means of detoxifying excess urea and creatinine, (2) its free radical scavenging property, and (3) its antioxidant property. The exact mechanism of antihyperammonemic effect PPEt has still to be investigated and isolation of the active constituents is required. |
| Databáze: | OpenAIRE |
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