Autosomal InDel polymorphisms for population genetic structure and differentiation analysis of Chinese Kazak ethnic group
| Autor: | Shao-Qing Wen, Yahao Chen, Tong Xie, Qian Dong, Chunmei Shen, Bofeng Zhu, Li Zhang, Yuanyuan Wei, Xiaoye Jin, Yuxin Guo, Tingting Kong, Yuling Mu, Boyan Zhou |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Genetics education.field_of_study business.industry Population Medical laboratory Ethnic group Population genetics population genetics Forensic science 03 medical and health sciences 030104 developmental biology Oncology Kazak group Medicine InDel phylogenetic tree Biostatistics business education Indel China interpopulation differentiation Demography Research Paper |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | // Tingting Kong 1, 2, 3 , Yahao Chen 4 , Yuxin Guo 1, 2, 5 , Yuanyuan Wei 1, 2 , Xiaoye Jin 1, 2, 5 , Tong Xie 3 , Yuling Mu 5 , Qian Dong 5 , Shaoqing Wen 6 , Boyan Zhou 6, 7 , Li Zhang 8 , Chunmei Shen 9 and Bofeng Zhu 1, 2, 3 1 Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi’an Jiaotong University, Xi’an, P. R. China 2 Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi’an Jiaotong University, Xi’an, P. R. China 3 Department of Forensic Genetics, School of Forensic Medicine, Southern Medical University, Guangzhou, P. R. China 4 Laboratory Medicine Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, P. R. China 5 College of Medicine & Forensics, Xi’an Jiaotong University Health Science Center, Xi’an, P. R. China 6 State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, P. R. China 7 State Key Laboratory of Genetic Engineering and Institute of Biostatistics, School of Life Sciences, Fudan University, Shanghai, P. R. China 8 Department of Gastroenterology, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, P. R. China 9 Institute of Brain and Behavioral Sciences, College of Life Sciences, Shaanxi Normal University, Xi’an, P. R. China Correspondence to: Bofeng Zhu, email: zhubofeng7372@126.com Keywords: Kazak group, InDel, population genetics, interpopulation differentiation, phylogenetic tree Received: March 08, 2017 Accepted: April 12, 2017 Published: May 12, 2017 ABSTRACT In the present study, we assessed the genetic diversities of the Chinese Kazak ethnic group on the basis of 30 well-chosen autosomal insertion and deletion loci and explored the genetic relationships between Kazak and 23 reference groups. We detected the level of the expected heterozygosity ranging from 0.3605 at HLD39 locus to 0.5000 at HLD136 locus and the observed heterozygosity ranging from 0.3548 at HLD39 locus to 0.5283 at HLD136 locus. The combined power of discrimination and the combined power of exclusion for all 30 loci in the studied Kazak group were 0.999999999999128 and 0.9945, respectively. The dataset generated in this study indicated the panel of 30 InDels was highly efficient in forensic individual identifcation but may not have enough power in paternity cases. The results of the interpopulation differentiations, PCA plots, phylogenetic trees and STRUCTURE analyses showed a close genetic affiliation between the Kazak and Uigur group. |
| Databáze: | OpenAIRE |
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