Lipidomic changes of LDL after consumption of Camelina sativa oil, fatty fish and lean fish in subjects with impaired glucose metabolism—A randomized controlled trial

Autor: Maria Lankinen, Arja T. Erkkilä, Minna Holopainen, Ursula Schwab, Reijo Käkelä, Maija Ruuth, Katariina Öörni, Linda Fredrikson, Monika Bhalke, Suvi Manninen
Přispěvatelé: Helsinki Institute of Life Science HiLIFE, Molecular and Integrative Biosciences Research Programme, Faculty of Biological and Environmental Sciences, Functional Lipidomics Group, Medicum, Research Programs Unit
Rok vydání: 2021
Předmět:
Male
ALPHA-LINOLENIC ACID
Endocrinology
Diabetes and Metabolism
030204 cardiovascular system & hematology
n-3 PUFA
SUPPLEMENTATION
Eating
chemistry.chemical_compound
0302 clinical medicine
Medicine
Food science
ELECTROSPRAY
2. Zero hunger
chemistry.chemical_classification
0303 health sciences
Nutrition and Dietetics
biology
alpha-Linolenic acid
Low-density lipoprotein
Fishes
Camellia
Middle Aged
Lipidome
QUANTITATIVE-ANALYSIS
Eicosapentaenoic acid
3. Good health
Lipoproteins
LDL
Docosahexaenoic acid
Cholesteryl ester
Female
lipids (amino acids
peptides
and proteins)
Cardiology and Cardiovascular Medicine
Polyunsaturated fatty acid
Spectrometry
Mass
Electrospray Ionization
Camelina sativa
LOW-DENSITY-LIPOPROTEIN
Protein Aggregates
03 medical and health sciences
Fish Oils
Dietary Fats
Unsaturated
Fatty Acids
Omega-3
Glucose Intolerance
Lipidomics
Internal Medicine
Animals
Humans
Plant Oils
PARTICLES
Aged
030304 developmental biology
business.industry
AGGREGATION
biology.organism_classification
Fish
chemistry
1182 Biochemistry
cell and molecular biology
business
Zdroj: Journal of Clinical Lipidology. 15:743-751
ISSN: 1933-2874
DOI: 10.1016/j.jacl.2021.08.060
Popis: Background: There is little knowledge on the effects of alpha-linolenic acid (ALA) and n-3 long chain polyunsaturated fatty acids (n-3 LCPUFA) on the LDL lipidome and aggregation of LDL particles. Objective: We examined if consumption of Camelina sativa oil (CSO) as a source of ALA, fatty fish (FF) as a source of n-3 LCPUFA and lean fish (LF) as a source of fish protein affect the lipidome of LDL as compared to a control diet. Methods: Participants with impaired glucose tolerance (39 women and 40 men) were randomized to 4 study groups (CSO providing 10 g/d ALA, FF and LF [both 4 fish meals/wk] and control limiting their fish and ALA intake) in a 12-week, parallel trial. Diets were instructed and dietary fats were provided to the participants. The lipidome of LDL particles isolated from samples collected at baseline and after intervention was analyzed with electrospray ionization-tandem mass spectrometry. Results: In the CSO group, the relative concentrations of saturated and monounsaturated cholesteryl ester species in LDL decreased and the species with ALA increased. In the FF group, LDL phosphatidylcholine (PC) species containing n-3 LCPUFA increased. There was a significant positive correlation between the change in total sphingomyelin and change in LDL aggregation, while total PC and triunsaturated PC species were inversely associated with LDL aggregation when all the study participants were included in the analysis. Conclusion: Dietary intake of CSO and FF modifies the LDL lipidome to contain more polyunsaturated and less saturated lipid species. The LDL surface lipids are associated with LDL aggregation. (c) 2021 National Lipid Association. Published by Elsevier Inc. This is an open access article under the CC BY license ( http://creativecommons.org/licenses/by/4.0/ )
Databáze: OpenAIRE
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