A New Class of Smart Gadolinium Contrast Agent for Tissue pH Probing Using Magnetic Resonance Imaging
| Autor: | Mozhdeh Seyyedhamzeh, Mohammed Zourob, Ali Husain, Rik Achten, Fouzi Mouffouk, Abdullah Alhendal, Hacene Serrai, Sourav Bhaduri |
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| Rok vydání: | 2020 |
| Předmět: |
Contrast Media
Pharmaceutical Science Gadolinium Gadolinium contrast Chemistry Techniques Synthetic sensors LACTATE 01 natural sciences 030218 nuclear medicine & medical imaging Analytical Chemistry Matrix (chemical analysis) Mice 0302 clinical medicine Neoplasms Drug Discovery Medicine and Health Sciences WATER Contrast (vision) Tissue Distribution Medical diagnosis Volume concentration media_common Molecular Structure medicine.diagnostic_test pH PROTON CHEMICAL-EXCHANGE Hydrogen-Ion Concentration Magnetic Resonance Imaging Organ Specificity Chemistry (miscellaneous) Molecular Medicine MRI CONTRAST CEST MRI Technology and Engineering Materials science media_common.quotation_subject 010402 general chemistry Article lcsh:QD241-441 cancer imaging 03 medical and health sciences lcsh:Organic chemistry In vivo medicine Animals Humans Sensitivity (control systems) Physical and Theoretical Chemistry Organic Chemistry Magnetic resonance imaging 0104 chemical sciences Disease Models Animal Models Chemical Biomedical engineering |
| Zdroj: | Molecules Volume 25 Issue 7 MOLECULES Molecules, Vol 25, Iss 7, p 1513 (2020) |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules25071513 |
| Popis: | Detecting tissue pH in vivo is extremely vital for medical diagnosis and formulation of treatment decisions. To this end, many investigations have been carried out to develop an accurate and efficient method of in vivo pH measurement. Most of the techniques developed so far suffer from inadequate accuracy, due to poor sensitivity at low concentration of the target or nonspecific interactions within the tissue matrix. To overcome these issues, we describe herein the development of a simple, yet reliable, way to estimate pH with high precision using a Gd(III)-DOTA-silyl-based acid-labile group as a pH-sensitive contrast agent with Magnetic Resonance Imaging (MRI). With this method, a change in T 1 weighted image intensity of the newly developed pH-sensitive contrast is directly linked to the proton concentration in the media. As a result, we were able estimate the pH of the target with 95% reliability. |
| Databáze: | OpenAIRE |
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