Botulinum toxin in preparation of oral cavity for microsurgical reconstruction
| Autor: | Sara Di Lorenzo, Francesco Moschella, Renato Costa, Bartolo Corradino, Carmela Mossuto |
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| Přispěvatelé: | Corradino, B, Di Lorenzo, S, Mossuto, C, Costa, RP, Moschella, F. |
| Rok vydání: | 2009 |
| Předmět: |
Saliva
Reconstructive surgery medicine.medical_specialty Microsurgery Botulinum Toxins Type A/administration & dosage* Humans Microsurgery* Mouth Floor/surgery Mouth Neoplasms/surgery* Neck Dissection Neoplasm Invasiveness Preoperative Care* Salivary Glands/drug effects* Salivation/drug effects Surgical Flaps Tongue Neoplasms/surgery Fistula medicine.medical_treatment Salivary Glands Surgical Flaps Major Salivary Gland Preoperative Care Medicine Humans Oral Cavity Carcinoma Neoplasm Invasiveness Botulinum Toxins Type A Mouth Floor business.industry General Medicine medicine.disease Botulinum toxin Surgery Tongue Neoplasms Otorhinolaryngology Neck Dissection Mouth Neoplasms business Complication Salivation medicine.drug |
| Zdroj: | Acta oto-laryngologica. 130(1) |
| ISSN: | 1651-2251 |
| Popis: | CONCLUSIONS: Infiltration of botulinum toxin in the major salivary glands allows a temporary reduction of salivation that begins 8 days afterwards and returns to normal within 2 months. The inhibition of salivary secretion, carried out before the oral cavity reconstructive surgery, could allow a reduction of the incidence of oro-cutaneous fistulas and local complications. OBJECTIVES: Saliva stagnation is a risk factor for patients who have to undergo reconstructive microsurgery of the oral cavity, because of fistula formation and local complications in the oral cavity. The authors suggest infiltration of botulinum toxin in the major salivary glands to reduce salivation temporarily during the healing stage. PATIENTS AND METHODS: During the preoperative stage, 20 patients with oral cavity carcinoma who were candidates for microsurgical reconstruction underwent sialoscintigraphy and a quantitative measurement of the salivary secretion. Injection of botulinum toxin was carried out in the salivary glands 4 days before surgery. The saliva quantitative measurement was repeated 3 and 8 days after infiltration, sialoscintigraphy after 15 days. RESULTS: In all cases, the saliva quantitative measurement revealed a reduction of 50% and 70% of the salivary secretion after 72 h and 8 days, respectively. A lower rate of local complications was observed. |
| Databáze: | OpenAIRE |
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