Murine pheromone proteins constitute a context-dependent combinatorial code governing multiple social behaviors
| Autor: | Darren W. Logan, Annika Cichy, Tobias Ackels, Marc Spehr, Tsung-Han Kuo, Sandeepa Dey, Angeldeep W. Kaur, Maria Kateri, Cristen K. Hays, Tobias F. Marton, Lisa Stowers |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
Vomeronasal organ Context (language use) Sensory system Biology Ligands General Biochemistry Genetics and Molecular Biology Article Pheromones Mice medicine Animals Social Behavior Mice Inbred BALB C Major urinary proteins Aggression Biochemistry Genetics and Molecular Biology(all) Repertoire Proteins Mice Inbred C57BL Immunology Pheromone Female medicine.symptom Neuroscience Social behavior |
| Popis: | SummaryDuring social interactions, an individual’s behavior is largely governed by the subset of signals emitted by others. Discrimination of “self” from “other” regulates the territorial urine countermarking behavior of mice. To identify the cues for this social discrimination and understand how they are interpreted, we designed an olfactory-dependent countermarking assay. We find major urinary proteins (MUPs) sufficient to elicit countermarking, and unlike other vomeronasal ligands that are detected by specifically tuned sensory neurons, MUPs are detected by a combinatorial strategy. A chemosensory signature of “self” that modulates behavior is developed via experience through exposure to a repertoire of MUPs. In contrast, aggression can be elicited by MUPs in an experience-independent but context-dependent manner. These findings reveal that individually emitted chemical cues can be interpreted based on their combinatorial permutation and relative ratios, and they can transmit both fixed and learned information to promote multiple behaviors. |
| Databáze: | OpenAIRE |
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