Folic Acid Functionalized Zirconium-Based Metal-Organic Frameworks as Drug Carriers for Active Tumor-Targeted Drug Delivery
| Autor: | Xiao-Jun Sun, Xin Zhang, Jing-Li Sheng, Yujie Feng, Hong Dong, Feng-Ming Zhang, Xiang-Bin Meng, Gui-Xin Yang |
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| Rok vydání: | 2018 |
| Předmět: |
Drug
Cell Survival media_common.quotation_subject Nanoparticle Antineoplastic Agents 02 engineering and technology 010402 general chemistry 01 natural sciences Catalysis Cell Line chemistry.chemical_compound Mice Folic Acid Molecule Animals Humans Formate Metal-Organic Frameworks media_common Drug Carriers Microscopy Confocal Chemistry Organic Chemistry General Chemistry 021001 nanoscience & nanotechnology Controlled release Combinatorial chemistry 0104 chemical sciences Drug Liberation Drug delivery Metal-organic framework Fluorouracil Zirconium 0210 nano-technology Drug carrier HeLa Cells |
| Zdroj: | Chemistry (Weinheim an der Bergstrasse, Germany). 24(64) |
| ISSN: | 1521-3765 |
| Popis: | Nanoscale metal-organic frameworks (NMOFs) have proven to be a class of promising drug carriers as a result of their high porosity, crystalline nature with definite structure information, and potential for further functionality. However, MOF-based drug carriers with active tumor-targeting function have not been extensively researched until now. Here we show a strategy for constructing active tumor-targeted NMOF drug carriers by anchoring functional folic acid (FA) molecules onto the metal clusters of NMOFs. Two zirconium-based MOFs, MOF-808 and NH2 -UiO-66, were chosen as models to reduce to the nanoscale for application as drug carriers, and then the terminal carboxylates of FA molecules were coordinated to Zr6 clusters on the surfaces of the nanoparticles by substitution of the original formate or terminal -OH ligands. The successful modification with FA was confirmed by solid-state 13 C MAS NMR and UV/Vis spectroscopy and other characterization methods. Drug loading and controlled release behavior at different pH were determined by utilizing the anticancer drug 5-fluorouracil (5-FU) as the model drug. Confocal laser scanning microscopy measurements further demonstrated that 5-FU-loaded FA-NMOFs have excellent targeting ability through the efficient cellular uptake of FA-NMOFs. This work opens up a new avenue to the construction of active tumor-targeted NMOF-based drug carriers with potential for cancer therapies. |
| Databáze: | OpenAIRE |
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