Exposure to ozone reduces influenza disease severity and alters distribution of influenza viral antigens in murine lungs
| Autor: | Y C Zee, J A Wolcott, J W Osebold |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Biology
Antibodies Viral medicine.disease_cause Applied Microbiology and Biotechnology Virus Mice Ozone Orthomyxoviridae Infections Interferon Influenza A virus medicine Animals Respiratory system Antigens Viral Lung Ecology Antibody titer Respiratory infection Virology Pulmonary Alveoli medicine.anatomical_structure Immunology Respiratory epithelium Female Interferons Research Article Food Science Biotechnology medicine.drug |
| Zdroj: | Applied and Environmental Microbiology. 44:723-731 |
| ISSN: | 1098-5336 0099-2240 |
| DOI: | 10.1128/aem.44.3.723-731.1982 |
| Popis: | Exposure to ambient levels of ozone (0.5 ppm) was shown to alter the pathogenesis of respiratory infection after aerosol infection of mice with influenza A virus. A semiquantitative method for determination of the sites of virus replication by direct immunofluorescence indicated that exposure to ozone reduced the involvement of respiratory epithelium in the infectious process and resulted in a less widespread infection of the alveolar parenchyma. Furthermore, the ozone-mediated alteration in viral antigen distribution was consistent with significantly reduced influenza disease mortality and prolonged survival time, but only when the oxidant was present during the course of infection. Reduced disease severity in ozone-exposed animals appeared to be independent of peak pulmonary virus titers, pulmonary interferon titers, and pulmonary and serum-neutralizing antibody titers. These studies suggested that the distribution of influenza virus in the murine lung was a key factor in disease severity. |
| Databáze: | OpenAIRE |
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