Long‐term cognitive outcomes after cerebral sinovenous thrombosis in childhood
| Autor: | Nomazulu Dlamini, Robyn Westmacott, Mahmoud Slim, Ivanna Yau, Daune MacGregor, Mahendranath Moharir, aly aziz, Kathleen Andres, Gabrielle deVeber |
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| Rok vydání: | 2020 |
| Předmět: |
Male
030506 rehabilitation Pediatrics medicine.medical_specialty Intelligence Child Behavior Neuropsychological Tests Logistic regression Executive Function Sinus Thrombosis Intracranial 03 medical and health sciences 0302 clinical medicine Developmental Neuroscience Interquartile range Reaction Time medicine Humans Attention Cognitive Dysfunction Child Language Problem Behavior Working memory business.industry Infant Newborn Neuropsychology Infant Cognition Odds ratio Confidence interval Memory Short-Term Child Preschool Pediatrics Perinatology and Child Health Female Observational study Neurology (clinical) 0305 other medical science business 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | Developmental Medicine & Child Neurology. 62:1437-1443 |
| ISSN: | 1469-8749 0012-1622 |
| DOI: | 10.1111/dmcn.14664 |
| Popis: | Aim To assess long-term cognitive function in children after cerebral sinovenous thrombosis (CSVT). Method Children with CSVT, who had neuropsychological testing for intellectual ability, executive function, attention, language, or behavior, were included in a prospective observational study. Outcomes were compared with normative means using one-sample t-tests. Predictors of abnormal function were examined using logistic regression. Results Fifty children with CSVT were included (median age at diagnosis 2y 10mo, interquartile range 7d-6y 10mo; 35 males, 15 females). The median follow-up time was 4 years 2 months (interquartile range 2y 8mo-6y 4mo). Compared with normative means, children with CSVT had lower mean (± standard deviation) full-scale IQ, working memory, and processing speed scores (93.3±16, p=0.01; 93.6±16, p=0.04; 93.7±15.3, p=0.02 respectively). They also had lower scores in executive function, attention, and language domains. Refractory seizure at presentation was associated with a trend in behavioral problems (odds ratio [OR] 6.3, 95% confidence interval [CI] 0.9-46, p=0.07). Females were less likely to experience processing speed difficulties (OR 0.22, 95% CI 0.04-1.3, p=0.09). Incomplete recanalization was associated with a greater risk of abnormal verbal comprehension (OR 5.3, 95% CI 0.93-30.5, p=0.059). Interpretation Children with CSVT as a group performed below age expectations on standardized neuropsychological tests, although there was variability across individuals and cognitive domains. Larger studies are needed to evaluate predictors of cognitive deficits in children with CSVT. |
| Databáze: | OpenAIRE |
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