Diet Supplementation with a Bioactive Pomace Extract from Olea europaea Partially Mitigates Negative Effects on Gut Health Arising from a Short-Term Fasting Period in Broiler Chickens

Autor:	Jose J Pastor, David Menoyo, Marta Blanch, Javier Herrero-Encinas
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Crypt short-term fasting Orosomucoid 03 medical and health sciences chemistry.chemical_compound Lactulose Animal science lcsh:Zoology medicine lcsh:QL1-991 030304 developmental biology anti-inflammatory 0303 health sciences Intestinal permeability lcsh:Veterinary medicine General Veterinary biology olive pomace extract Chemistry intestinal permeability Monensin 0402 animal and dairy science Broiler 04 agricultural and veterinary sciences biology.organism_classification medicine.disease gut health 040201 dairy & animal science broiler chicken Olea biology.protein lcsh:SF600-1100 Animal Science and Zoology Mannitol medicine.drug
Zdroj:	Animals, Vol 10, Iss 2, p 349 (2020) Animals Volume 10 Issue 2
ISSN:	2076-2615
Popis:	The effects of supplementing chicken diets with an olive pomace extract (OE) from Olea europaea on performance and gut health after a challenge of intestinal permeability (IP) increase were studied. Treatments included a control diet with no additives (CF), and diets supplemented with 100 ppm of monensin (MF) or with 500 (OE500F) and 1500 ppm (OE1500F) of an OE. At 14 d, all birds, except those allocated in a control group (CNF), were submitted to a 15.5 h short-term fasting period to induce IP increase. Fasting increased (p < 0.05) lactulose/mannitol ratio and Alpha 1 Acid Glycoprotein concentration, and reduced (p < 0.001) villus/crypt ratio. Moreover, a down-regulation of Claudin-1 (p < 0.05), an up-regulation of TLR4 and IL-8 (p < 0.05) ileal gene expression was observed in CF birds compared to CNF. OE500F treatment reduced duodenal crypt depth compared to CF (p < 0.05 OE linear effect). Mannitol concentration and ileal IL-8 expression were reduced in OE500F compared to CF and OE1500F (p = 0.05). Fasting challenge induced an increase in IP triggering an inflammatory response. Supplementation of OE up to 1500 ppm did not affect growth performance and alleviated some of the negative effects of the fasting challenge.
Databáze:	OpenAIRE
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