Structured triglycerides versus physical mixtures of medium- and long-chain triglycerides for parenteral nutrition in surgical or critically ill adult patients: Systematic review and meta-analysis
| Autor: | Heidi Schuster, Guo Hao Wu, Orietta Zaniolo, Ewald Schlotzer, Lorenzo Pradelli |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Databases Factual media_common.quotation_subject Critical Illness Subgroup analysis Critical Care and Intensive Care Medicine Risk Assessment 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans 030212 general & internal medicine Aspartate Aminotransferases Adverse effect Intensive care medicine Triglycerides media_common Randomized Controlled Trials as Topic Selection bias 030109 nutrition & dietetics Nutrition and Dietetics business.industry Nitrogen balance Reproducibility of Results Alanine Transaminase Length of Stay Parenteral nutrition Structured triglycerides Clinical trial Meta-analysis Treatment Outcome Data extraction Adverse events Pre-albumin Risk assessment business |
| Zdroj: | Clinical Nutrition. |
| ISSN: | 0261-5614 |
| DOI: | 10.1016/j.clnu.2016.01.004 |
| Popis: | SummaryIntroductionNew generations of parenteral lipid emulsions combine Long Chain Triglycerides (LCTs) with Medium Chain Triglycerides (MCTs) either by physically mixing MCT- and LCT-containing oils or by using synthetically structured triglycerides (STGs). In order to clarify some open issues relating to their comparative effect, in particular in terms of clinical outcomes, pertinent evidence was systematically identified, reviewed and meta-analyzed.MethodsPubMed, Scopus, Wanfang Data, China Hospital Knowledge Database and Google Scholar were searched for published clinical trials comparing STGs vs. MCTs/LCTs PN regimens administered over 5–7 days in surgical and/or critically ill patients. Two independent investigators performed screening and data extraction using a predefined list of parameters. Data were pooled using RevMan® 5.2. Quality of evidence was assessed according to Cochrane's risk of bias tool. Pre-specified high quality (HQ), incremental analyses and a post hoc subgroup analysis were performed.Results21 studies were included. The meta-analysis revealed a significantly better cumulative nitrogen balance (Std. mean difference [95% CI]) (1.34 [0.98–1.7], p |
| Databáze: | OpenAIRE |
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