Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion
| Autor: | Karina Liuba, Claus Nerlov, Stefan Jovinge, Philipp Sasse, Wilhelm Roell, Simon R.W. Stott, Jens M. Nygren, Martin Breitbach, Lina Thorén, Anders Björklund, Bernd K. Fleischmann, Caroline Geisen, Deniz Kirik, Sten Eirik W. Jacobsen |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Cell type
Myeloid Cell Green Fluorescent Proteins Inflammation Bone Marrow Cells Mice Transgenic Mice SCID Biology Cell Fusion Mice Purkinje Cells medicine Animals Cell Lineage Myeloid Cells Myocytes Cardiac Lymphocytes Muscle Skeletal Bone Marrow Transplantation Transplantation Chimera Cell fusion Radiation Cell Biology Cell cycle Hematopoietic Stem Cells Cell biology Haematopoiesis medicine.anatomical_structure Hepatocytes Female Stem cell medicine.symptom |
| Popis: | Recent studies have suggested that regeneration of non-haematopoietic cell lineages can occur through heterotypic cell fusion with haematopoietic cells of the myeloid lineage. Here we show that lymphocytes also form heterotypic-fusion hybrids with cardiomyocytes, skeletal muscle, hepatocytes and Purkinje neurons. However, through lineage fate-mapping we demonstrate that such in vivo fusion of lymphoid and myeloid blood cells does not occur to an appreciable extent in steady-state adult tissues or during normal development. Rather, fusion of blood cells with different non-haematopoietic cell types is induced by organ-specific injuries or whole-body irradiation, which has been used in previous studies to condition recipients of bone marrow transplants. Our findings demonstrate that blood cells of the lymphoid and myeloid lineages contribute to various non-haematopoietic tissues by forming rare fusion hybrids, but almost exclusively in response to injuries or inflammation. |
| Databáze: | OpenAIRE |
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