A study of the distribution and retention of cadmium-115 in the albino rat
| Autor: | R. U. Byerrum, C. A. Hoppert, C. F. Decker |
|---|---|
| Rok vydání: | 1957 |
| Předmět: |
inorganic chemicals
medicine.medical_specialty Cadmium Kidney Biophysics chemistry.chemical_element Urine Biochemistry Rats Excretion chemistry.chemical_compound Endocrinology medicine.anatomical_structure chemistry Oral administration Internal medicine medicine Animals Cadmium nitrate Distribution (pharmacology) Molecular Biology Feces |
| Zdroj: | Archives of Biochemistry and Biophysics. 66:140-145 |
| ISSN: | 0003-9861 |
| DOI: | 10.1016/0003-9861(57)90544-1 |
| Popis: | 1. 1. A single oral dose of cadmium administered as cadmium nitrate was absorbed only to a small extent, and over 90% of the ingested dose was excreted by way of the gut in 15 days. The largest fraction of the small amount absorbed is found in kidney and liver tissues. 2. 2. After a single intravenous injection of cadmium nitrate, over 65% of the total administered cadmium was found in the liver tissue. Kidney tissue also contained an appreciable amount of cadmium. Whereas liver and kidney tissues retained cadmium for long periods of time, the cadmium content of lung tissue decreased. Approximately 20% of the original intravenous dose was excreted by way of the feces in the first 72 hr. after injection, but little or no excretion by way of the urine was observed. |
| Databáze: | OpenAIRE |
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