Placebo-controlled trial of potassium supplements in black patients with mild essential hypertension
| Autor: | Obel Ao |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Potassium Placebo-controlled study chemistry.chemical_element Black People Blood Pressure Essential hypertension Placebo Gastroenterology Excretion Random Allocation Double-Blind Method Oral administration Internal medicine medicine Humans Pharmacology Clinical Trials as Topic business.industry Middle Aged medicine.disease Endocrinology Blood pressure Tolerability chemistry Hypertension Female Cardiology and Cardiovascular Medicine business Blood Chemical Analysis |
| Zdroj: | Journal of cardiovascular pharmacology. 14(2) |
| ISSN: | 0160-2446 |
| Popis: | Forty-eight black patients with mildly increased blood pressure (BP) that had not yet been subjected to treatment took part in a double-blind clinical trial of the efficacy and tolerability of oral potassium supplements (64 mmol daily) versus a matching placebo (made of starch with coating) in a 16-week study. Potassium supplements produced a significant decrease in mean supine and standing BP within 4 weeks after treatment inception. Urinary potassium excretion increased significantly in the 24 patients who received potassium supplements (p less than 0.001). No significant changes occurred in plasma sodium and potassium concentrations or in urinary excretion of sodium during the study. All patients completed the trial without experiencing any notable untoward effects. These results are consistent with the premise that oral potassium supplements may exert hypotensive effects of clinically significant degree in patients with mild hypertension. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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